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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Inflammation Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1475414

Association of Early Aspirin Use with 90-day Mortality in Patients with Sepsis: an PSM analysis of the MIMIC-IV Database

Provisionally accepted
Wenyuan Zhang Wenyuan Zhang 1*Chunsheng Huang Chunsheng Huang 2Qiaoling Tong Qiaoling Tong 3Zhihao Pan Zhihao Pan 2*
  • 1 The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China
  • 2 Department of Anesthesiology, Ningbo Medical Center Lihuili Hospital, Medical School of Ningbo University, Ningbo, China
  • 3 Department of otolaryngology, HwaMei Hospital, University Of Chinese Academy Of Sciences, Ningbo, Zhejiang Province, China

The final, formatted version of the article will be published soon.

    Objective: In addition to its antiplatelet and anti-inflammatory properties, aspirin inhibits bacterial proliferation directly. The potential benefits of aspirin may enhance the prognosis for sepsis patients. However, little is known about the effects of early aspirin administration. This study aimed to examine the correlation between the administration of aspirin at an early stage and the 90day mortality rate among sepsis patients.In order to distinguish between septic patients who received early aspirin treatment and those who did not, queries were conducted on the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. The principal metric utilized was 90-day mortality. We determined the association between early aspirin use and 90-day mortality using multivariate Cox regression, and propensity score matching (PSM) was utilized to validate our findings. The analyses of the subgroups have been completed.Results: Our analysis comprised 28,425 septic patients, of whom 7,568 (26.6%) received aspirin within 24 h of intensive care unit (ICU) admission.The aspirin users group had a lower 90-day mortality than the aspirin nonusers group [1,624 (21.8%) vs. 2,035 (27.3%), P < 0.001]. The logistic regression showed that early aspirin use was associated with a lower 90-day mortality (OR, 0.74, 95% CI, 0.69-0.80, P < 0.001). K-M curve analysis showed that the 90-day mortality of the aspirin users group was significantly lower than that of the aspirin nonusers group (P < 0.001). Subgroup analysis revealed comparable relationships between early aspirin use and 90-day mortality among individuals.In conclusion, early aspirin use was associated with decreased in-hospital and 90-day mortality in septic patients, emphasizing the significance of early aspirin use administration in the ICU.

    Keywords: Aspirin, Sepsis, Intensive Care Unit, 90-day mortality, Propensity score matching

    Received: 03 Aug 2024; Accepted: 18 Dec 2024.

    Copyright: © 2024 Zhang, Huang, Tong and Pan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Wenyuan Zhang, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China
    Zhihao Pan, Department of Anesthesiology, Ningbo Medical Center Lihuili Hospital, Medical School of Ningbo University, Ningbo, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.