Editorial: The pharmacological modulation of angiogenesis

Editorial on the Research Topic
The pharmacological modulation of angiogenesis

This editorial aims to provide an overview of the complex process of angiogenesis and its implications for human health. Angiogenesis is a complex process with far-reaching implications for human health. Its dysregulation can contribute to a myriad of diseases, including cancer, diabetic retinopathy, and impaired wound repair (Pessolano et al., 2018; Pessolano et al., 2021; Belvedere et al., 2022). Huang et al. demonstrated melatonin’s efficacy in promoting angiogenesis, suggesting a promising avenue for reconstructive surgery. Indeed, in his work, Ribatti’s points the attention on tumor vasculature, revealing critical differences between healthy and cancerous vessels, offering targets for anti-cancer therapies. Finally, the importance of the pharmacological modulation of angiogenesis in pathological conditions is explored. Ocular neovascularization represents an important Research Topic in the loss of vision. The anti-angiogenic and antioxidant effects of axitinib are analysed and suggested as potential treatment for diabetic retinopathy by Lazzara et al.

Deng et al. instead focuses on the ability of LSD-1 in controlling corneal neovascularization, identifying a potential therapeutic target. These studies collectively underscore the multifaceted nature of angiogenesis and its potential as a therapeutic target across various diseases.

Author contributions

EP: Writing–original draft, Writing–review and editing. RB: Writing–original draft, Writing–review and editing. SS: Writing–original draft, Writing–review and editing.

Funding

The authors declare that no financial support was received for the research, authorship, and/or publication of this article.

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

The authors declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

References

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Pessolano, E., Belvedere, R., Novizio, N., Filippelli, A., Perretti, M., Whiteford, J., et al. (2021). Mesoglycan connects Syndecan-4 and VEGFR2 through Annexin A1 and formyl peptide receptors to promote angiogenesis in vitro. FEBS J. 288 (22), 6428–6446. doi:10.1111/febs.16043

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