Mengjiao Xu ¹ peng feng ¹ jun yan ² Lei Li ^2*

• ¹ Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, Beijing Municipality, China
• ² Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China

Chronic obstructive pulmonary disease (COPD) is a prevalent chronic respiratory disease worldwide. Mitochondrial quality control mechanisms encompass processes such as mitochondrial biogenesis, fusion, fission, and autophagy, which collectively maintain the quantity, morphology, and function of mitochondria, ensuring cellular energy supply and the progression of normal physiological activities. However, in COPD, due to the persistent stimulation of harmful factors such as smoking and air pollution, mitochondrial quality control mechanisms often become deregulated, leading to mitochondrial dysfunction. Although Mmitochondrial dysfunction plays a pivotal role in the pathogenesis of COPD, contributing toinvolving inflammatory response, oxidative stress, cellular senescence, and other pathophysiological processes, therapeutic strategies targeting mitochondrial have yet to be fully explored. However, therapeutic strategies targeting mitochondria remain underexplored. This review highlights recent advances summarizes the latest research advances in mitochondrial dysfunction in COPD, focusing specifically on the role of mitochondrial quality control mechanisms and their dysregulation in disease progression .in COPD development and how their dysregulation exacerbates disease progression. We emphasize the significance of mitochondria in the pathophysiological processes of COPD and explore potential strategies to regulate mitochondrial quality and improve mitochondrial function through mitochondrial interventions, aiming to treat COPD effectively.Additionally, we analyze the limitations and challenges of existing therapeutic strategies, aiming to provide new insights and methods for COPD treatment.