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REVIEW article

Front. Pharmacol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1468977
This article is part of the Research Topic Plant-derived Therapeutics and Traditional Medicine: Innovations, Challenges, and Opportunities in Breast Cancer Treatment View all 3 articles

Plant protein-derived anti-breast cancer peptides: sources, therapeutic approaches, mechanisms, and nanoparticle design

Provisionally accepted
Deju Zhang Deju Zhang 1Ying Yuan Ying Yuan 2Qingdong Zeng Qingdong Zeng 3Juan Xiong Juan Xiong 3Yiming Gan Yiming Gan 1Kai Jiang Kai Jiang 4Ni Xie Ni Xie 2*
  • 1 The University of Hong Kong, Pokfulam, Hong Kong, SAR China
  • 2 Shenzhen Second People's Hospital, Shenzhen, Guangdong Province, China
  • 3 University of South China, Hengyang, Hunan Province, China
  • 4 Eastern Institute of Technology, Ningbo, Zhejiang Province, China

The final, formatted version of the article will be published soon.

    Breast cancer causes the deaths of approximately 685,000 women annually, posing a severe threat to women's health. Consequently, there is an urgent need for low-cost, low-toxicity and effective therapeutic methods to prevent or mitigate breast cancer progression. PDBP are natural, non-toxic, and affordable substances and have demonstrated excellent anti-breast cancer activities in inhibiting proliferation, migration, and invasion, and promoting apoptosis both in vitro and in vivo, thus effectively preventing or inhibiting breast cancer. However, there are no comprehensive reviews summarizing the effects and mechanisms of PDBP on the treatment of breast cancer. Therefore, this review described the inhibitory effects and mechanisms of active peptides from different plant protein sources on breast cancer. Additionally, we summarized the advantages and preparation methods of plant protein-derived anticancer peptide-encapsulated nanoparticles and their effects in inhibiting breast cancer. This review provides a scientific basis for understanding the anti-breast cancer mechanisms of PDBP and offers guidance for the development of therapeutic adjuvants enriched with these peptides.

    Keywords: Plant-derived peptides, breast cancer, Nanoparticles, Anti-breast cancer, Legume protein

    Received: 22 Jul 2024; Accepted: 19 Nov 2024.

    Copyright: © 2024 Zhang, Yuan, Zeng, Xiong, Gan, Jiang and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ni Xie, Shenzhen Second People's Hospital, Shenzhen, Guangdong Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.