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REVIEW article

Front. Pharmacol.
Sec. Ethnopharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1468850

The potential of natural products to inhibit abnormal aggregation of α-Synuclein in the treatment of Parkinson's disease

Provisionally accepted
凯霞 杨 凯霞 杨 1Zhongyue Lv Zhongyue Lv 1Guogang Lai Guogang Lai 1Cheng Zheng Cheng Zheng 2Feiteng Qi Feiteng Qi 1Cui Zhao Cui Zhao 1Kaikai Hu Kaikai Hu 1Xiao Chen Xiao Chen 1Fan Fu Fan Fu 1Jiayi Li Jiayi Li 1Guomin Xie Guomin Xie 1Haifeng Wang Haifeng Wang 1*Xiping Wu Xiping Wu 1*Wu Zheng Wu Zheng 2,3*
  • 1 Department of Neurology, Ningbo Medical Centre Li Huili Hospital, Ningbo, Zhejiang Province, China
  • 2 Ningbo Institute for Medicine & Biomedical Engineering Combined Innovation, Ningbo Medical Centre Lihuili Hospital, Ningbo, Zhejiang Province, China
  • 3 Wenzhou Medical University, Wenzhou, China

The final, formatted version of the article will be published soon.

    Parkinson's disease (PD), as a refractory neurological disorder with complex etiology, currently lacks effective therapeutic agents. Natural products (NPs), derived from plants, animals, or microbes, have shown promising effects in PD models through their antioxidative and anti-inflammatory properties, as well as the enhancement of mitochondrial homeostasis and autophagy. The misfolding and deposition of α-Synuclein (α-Syn), due to abnormal overproduction and impaired clearance, being central to the death of dopamine (DA) neurons. Thus, inhibiting α-Syn misfolding and aggregation has become a critical focus in PD discovery. This review highlights NPs that can reduce α-Syn aggregation by preventing its overproduction and misfolding, emphasizing their potential as novel drugs or adjunctive therapies for PD treatment, thereby providing further insights for clinical translation.

    Keywords: Parkinson's disease, α-Synuclein, Natural Products, Aggregation, misfolding

    Received: 26 Jul 2024; Accepted: 08 Oct 2024.

    Copyright: © 2024 杨, Lv, Lai, Zheng, Qi, Zhao, Hu, Chen, Fu, Li, Xie, Wang, Wu and Zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Haifeng Wang, Department of Neurology, Ningbo Medical Centre Li Huili Hospital, Ningbo, 315010, Zhejiang Province, China
    Xiping Wu, Department of Neurology, Ningbo Medical Centre Li Huili Hospital, Ningbo, 315010, Zhejiang Province, China
    Wu Zheng, Wenzhou Medical University, Wenzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.