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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1468374

Nanotechnological Prospective for Enhancing the Antibacterial Activity of Mupirocin and Cinnamon Essential Oil: A Combination Therapy Development and Optimization Based on Nanotechnology to Boost the Antibacterial Activity of Mupirocin and Cinnamon Essential Oil

Provisionally accepted
Bandar Aldhubiab Bandar Aldhubiab 1*Rashed M. Almuqbil Rashed M. Almuqbil 1*Tamer M. Shehata Tamer M. Shehata 1*Wafaa E. Soliman Wafaa E. Soliman 1*Heba S. Elsewedy Heba S. Elsewedy 2*
  • 1 King Faisal University, Al-Ahsa, Eastern Province, Saudi Arabia
  • 2 College of Pharmacy, University of Almaarefa, Riyadh, Saudi Arabia

The final, formatted version of the article will be published soon.

    The aim of current study was to develop a distinctive nanolipid formulation namely; nanostructured lipid carrier (NLC) that would deliver an antibacterial medication such as Mupirocin (MP). Additionally, cinnamon essential oil (CEO), which is reported to exhibit antibacterial activity, was utilized in the development process in an attempt to improve the influence of MP.Methods: As a consequence, different MP-NLC formulations were developed using Central Composite Design (CCD) approach. One optimized formula was selected and incorporated within pre-formulated gel matrix providing MP-NLC-gel formula for efficient topical application. MP-NLC-gel was assessed for its physical characters to check its suitability for topical application, and evaluated for its in vitro drug release over 6 hours. Further, it studied for its stability at different conditions; 25 ± 2°C and at 4 ± 3°C, for 6 months. Finally, the formulation was examined for its antibacterial performance against gram positive and negative bacteria.The developed topical NLC-gel formulation demonstrated pH 5.8, viscosity 14510 cP and spreadability 58.1 mm, which were seemed to be satisfactory properties for successful topical application. The drug was released successfully over 6 hours with 52.9 %. Additionally, it was stable in both storage conditions for 6 months since it displayed non-significant variations in its evaluated characters compared to fresh preparation. Ultimately, the developed gel formulation could inhibit growth of different bacterial strains, especially gram negative one.To sum up, these findings would demonstrate the efficiency of NLC prepared with CEO and incorporating MP to be a promising antibacterial lipid nanocarrier.

    Keywords: Mupirocin 1, Cinnamon essential oil 2, Nanostructured lipid carrier 3, Topical delivery 4, antibacterial activity 5

    Received: 21 Jul 2024; Accepted: 25 Oct 2024.

    Copyright: © 2024 Aldhubiab, Almuqbil, Shehata, Soliman and Elsewedy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Bandar Aldhubiab, King Faisal University, Al-Ahsa, 31982, Eastern Province, Saudi Arabia
    Rashed M. Almuqbil, King Faisal University, Al-Ahsa, 31982, Eastern Province, Saudi Arabia
    Tamer M. Shehata, King Faisal University, Al-Ahsa, 31982, Eastern Province, Saudi Arabia
    Wafaa E. Soliman, King Faisal University, Al-Ahsa, 31982, Eastern Province, Saudi Arabia
    Heba S. Elsewedy, College of Pharmacy, University of Almaarefa, Riyadh, Saudi Arabia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.