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SYSTEMATIC REVIEW article

Front. Pharmacol.
Sec. Obstetric and Pediatric Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1467325
This article is part of the Research Topic Precision Medicine in Pediatrics - Volume II View all 12 articles

Yinzhihuang injection as adjuvant treatment for neonatal hyperbilirubinemia: a systematic review and meta-analysis of randomized clinical trials

Provisionally accepted
JunQiang Li JunQiang Li Liyu Zhang Liyu Zhang *Zhongguo Chen Zhongguo Chen *Min Qin Min Qin *
  • Lincang Maternal and Child Health Centre, Lincang, China

The final, formatted version of the article will be published soon.

    Background: Neonatal hyperbilirubinemia (NH) is a common phenomenon for neonate inpatients, and Yinzhihuang (YZH) injection is a well-known Chinese herbal formula for the treatment of NH. This study aims to evaluate the efficacy of YZH injection on NH. Methods: A comprehensive literature search was performed in four Chinese databases [ China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature (CBM), China Science Journal Database (VIP), and Wan Fang ] and four English language databases ( PubMed, Web of Science, EMbase and the Cochrane Library ) from inception to April 16, 2024. Randomized controlled trials on YZH injection for NH were collected. Review Manager 5.4 software was used for meta-analysis and bias risk assessment.Result: Twenty-two trials involving 2714 neonates were included. Significant differences were detected between YZH injection group and control group for total effective rate (RR=1.15, 95%CI: 1.11 to 1.20, p ＜ 0.00001), serum bilirubin level (the third day,

    Keywords: Neonatal Hyperbilirubinemia, Yinzhihuang injection, Systematic review, Meta-analysis, Paediatrics

    Received: 19 Jul 2024; Accepted: 20 Nov 2024.

    Copyright: © 2024 Li, Zhang, Chen and Qin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Liyu Zhang, Lincang Maternal and Child Health Centre, Lincang, China
    Zhongguo Chen, Lincang Maternal and Child Health Centre, Lincang, China
    Min Qin, Lincang Maternal and Child Health Centre, Lincang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.