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SYSTEMATIC REVIEW article

Front. Pharmacol.
Sec. Ethnopharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1466677

Effects of Qingjin Huatan Decoction on Pulmonary Function and Inflammatory Mediators in Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Systematic Review and Metaanalysis

Provisionally accepted
Xuqin Du Xuqin Du 1*Yong Chen Yong Chen 2Ruodai Zhang Ruodai Zhang 3Lipeng Shi Lipeng Shi 2Yi Ren Yi Ren 2
  • 1 Chongqing College of Traditional Chinese Medicine, Chongqing, China
  • 2 Chongqing Traditional Chinese Medicine Hospital, Chongqing, China
  • 3 Chongqing Medical University, Chongqing, China

The final, formatted version of the article will be published soon.

    The inflammatory response is the main pathophysiological basis of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) and is a key factor leading to frequent exacerbations and disease progression. Suppressing the inflammatory response can improve pulmonary function, prognosis, and quality of life in AECOPD patients.To evaluate the effect of Qingjin Huatan decoction (QHD) on pulmonary function and inflammatory mediators in AECOPD patients.Methods: Randomized controlled trials (RCTs) on the treatment of AECOPD with QHD were retrieved from eight Chinese and English electronic databases up to May 31, 2024. The quality of the studies was assessed using the Cochrane Risk of Bias Tool and the modified Jadad scale. Statistical analysis, sensitivity analysis, and publication bias assessment were performed using Stata 17.0 software.A total of 40 RCTs involving 3,475 AECOPD patients were included. Compared to conventional treatment, QHD significantly improved pulmonary function, with increases in FEV1 (MD = 0.30, 95% CI: 0.26 to 0.34, p = 0.000), FVC (MD = 0.34, 95% CI: 0.27 to 0.41, p = 0.000),

    Keywords: Qingjin Huatan Decoction, Acute exacerbations of chronic obstructive pulmonary disease, Pulmonary Function, Inflammation Mediators, randomized controlled trials, Systematic review, Meta-analysis

    Received: 18 Jul 2024; Accepted: 10 Oct 2024.

    Copyright: © 2024 Du, Chen, Zhang, Shi and Ren. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xuqin Du, Chongqing College of Traditional Chinese Medicine, Chongqing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.