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REVIEW article
Front. Pharmacol.
Sec. Translational Pharmacology
Volume 15 - 2024 |
doi: 10.3389/fphar.2024.1466337
This article is part of the Research Topic Lipid-Based Formulations: From Design to Application View all articles
Composition of lipid nanoparticles for targeted delivery: application to mRNA therapeutics
Provisionally accepted- 1 Scientific Center for Translation Medicine, Sirius University, Sochi, Russia
- 2 Lomonosov Moscow State University, Moscow, Russia
- 3 Institute of Cytology and Genetics, Russian Academy of Sciences (RAS), Novosibirsk, Novosibirsk Oblast, Russia
Today, lipid nanoparticles (LNPs) are some of the main delivery systems for mRNA-based therapeutics. The scope of LNP applications in terms of RNA is not limited to antiviral vaccines but encompasses anticancer drugs and therapeutics for genetic (including rare) diseases. Such widespread use implies high customizability of targeted delivery of LNPs to specific organs and tissues. This review addresses vector-free options for targeted delivery of LNPs, namely the influence of lipid composition of these nanoparticles on their biodistribution. In the review, experimental studies are examined that are focused on the biodistribution of mRNA or of the encoded protein after mRNA administration via LNPs in mammals. We also performed a comprehensive analysis of individual lipids' functional groups that ensure biodistribution to desired organs. These data will allow us to outline prospects for further optimization of lipid compositions of nanoparticles for targeted delivery of mRNA therapeutics.
Keywords: Lipid nanoparticles, mRNA therapeutic, in vivo, nucleic acid delivery system, Drug Development, gene editing
Received: 17 Jul 2024; Accepted: 10 Sep 2024.
Copyright: © 2024 Vasileva, Zaborova, Shmykov, Ivanov and Reshetnikov. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Olga Zaborova, Lomonosov Moscow State University, Moscow, Russia
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