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REVIEW article

Front. Pharmacol.
Sec. Translational Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1466337
This article is part of the Research Topic Lipid-Based Formulations: From Design to Application View all articles

Composition of lipid nanoparticles for targeted delivery: application to mRNA therapeutics

Provisionally accepted
Olga Vasileva Olga Vasileva 1Olga Zaborova Olga Zaborova 1,2*Bogdan Shmykov Bogdan Shmykov 2Roman Ivanov Roman Ivanov 1Vasiliy Reshetnikov Vasiliy Reshetnikov 1,3
  • 1 Scientific Center for Translation Medicine, Sirius University, Sochi, Russia
  • 2 Lomonosov Moscow State University, Moscow, Russia
  • 3 Institute of Cytology and Genetics, Russian Academy of Sciences (RAS), Novosibirsk, Novosibirsk Oblast, Russia

The final, formatted version of the article will be published soon.

    Today, lipid nanoparticles (LNPs) are some of the main delivery systems for mRNA-based therapeutics. The scope of LNP applications in terms of RNA is not limited to antiviral vaccines but encompasses anticancer drugs and therapeutics for genetic (including rare) diseases. Such widespread use implies high customizability of targeted delivery of LNPs to specific organs and tissues. This review addresses vector-free options for targeted delivery of LNPs, namely the influence of lipid composition of these nanoparticles on their biodistribution. In the review, experimental studies are examined that are focused on the biodistribution of mRNA or of the encoded protein after mRNA administration via LNPs in mammals. We also performed a comprehensive analysis of individual lipids' functional groups that ensure biodistribution to desired organs. These data will allow us to outline prospects for further optimization of lipid compositions of nanoparticles for targeted delivery of mRNA therapeutics.

    Keywords: Lipid nanoparticles, mRNA therapeutic, in vivo, nucleic acid delivery system, Drug Development, gene editing

    Received: 17 Jul 2024; Accepted: 10 Sep 2024.

    Copyright: © 2024 Vasileva, Zaborova, Shmykov, Ivanov and Reshetnikov. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Olga Zaborova, Lomonosov Moscow State University, Moscow, Russia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.