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MINI REVIEW article

Front. Pharmacol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1463538
This article is part of the Research Topic The Role of Tumor Microenvironment in Malignant Progression and Target Validation View all articles

Cellular components of tumor microenvironment: understanding their role in lymphatic metastasis of tumors

Provisionally accepted
Ziyi Wang Ziyi Wang 1Zehui Li Zehui Li 1*Xiangyu Sun Xiangyu Sun 2*Yan Xu Yan Xu 1*
  • 1 Department of Surgical Oncology and General Surgery, First Affiliated Hospital of China Medical University., Shenyang, Liaoning Province, China
  • 2 Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning Province, Shenyang, Liaoning Province, China

The final, formatted version of the article will be published soon.

    Metastasis is the leading cause of cancer-related death in cancer patients. Tumor cells primarily spread through the hematogenous and lymphatic system. The underlying mechanisms of hematogenous metastasis have been well described over the past few decades. However, the understanding of the molecular mechanisms involved in lymphatic metastasis is still at an early stage. Tumor microenvironment (TME), primarily consisting of T cells, B cells, tumor-associated macrophages, neutrophils, and cancer-associated fibroblasts, has been implicated in the development of lymphatic metastasis. Recent studies have been reported that the dynamic and complex interplay between these cellular components of TME has great effects on lymphatic metastasis. Here, we discussed the paradoxical roles of these cellular component within the TME during lymphatic metastasis, as well as potential therapeutic opportunities to re-educate these cells within the TME to have anti-tumorigenic effects.

    Keywords: Tumor Microenvironment, immune cell, Lymph Node, Lymphatic Metastasis, Cancer

    Received: 12 Jul 2024; Accepted: 28 Oct 2024.

    Copyright: © 2024 Wang, Li, Sun and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zehui Li, Department of Surgical Oncology and General Surgery, First Affiliated Hospital of China Medical University., Shenyang, Liaoning Province, China
    Xiangyu Sun, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning Province, Shenyang, Liaoning Province, China
    Yan Xu, Department of Surgical Oncology and General Surgery, First Affiliated Hospital of China Medical University., Shenyang, Liaoning Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.