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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Cardiovascular and Smooth Muscle Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1463465
This article is part of the Research Topic Targets in Cardio-Oncology: Drug Effects and Mechanisms of Action View all articles

Lats-IN-1 Protects Cardiac Function and Promotes Regeneration After Myocardial Infarction by Targeting the Hippo Pathway

Provisionally accepted
Hua Shen Hua Shen 1Qing Wang Qing Wang 2Bohan Liu Bohan Liu 1Yihui Wang Yihui Wang 3Dandan Zhou Dandan Zhou 4*Lin Zhang Lin Zhang 1*Jinqiang Zhuang Jinqiang Zhuang 5*
  • 1 Department of Cardiovascular Surgery, PLA General Hospital, Beijing, Beijing Municipality, China
  • 2 Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China
  • 3 Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Shanghai, China
  • 4 Department of Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China
  • 5 Emergency Intensive Care Unit(EICU), The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China

The final, formatted version of the article will be published soon.

    In this study, we explored the efficacy of Lats-IN-1, a LATS1/2 kinase inhibitor that targets the Hippo pathway, as a novel treatment for myocardial infarction (MI), a leading cause of heart failure globally due to the loss of cardiomyocytes. Using male C57BL/6 mice subjected to surgically induced MI, we treated these models with Lats-IN-1 and assessed cardiac function, infarct size, cardiomyocyte proliferation, and apoptosis. Our findings demonstrate that Lats-IN-1 significantly improves cardiac function, evidenced by enhanced ejection fraction and reduced ventricular dimensions, alongside a notable decrease in infarct size and apoptosis rates. Furthermore, it increased cardiomyocyte proliferation, indicating its potential to promote cardiac repair and regeneration. By modulating the Hippo pathway and reducing apoptosis markers, Lats-IN-1 emerges as a promising therapeutic strategy for improving outcomes in heart diseases marked by cardiomyocyte loss, underscoring the critical role of the Hippo pathway in cardiac regeneration.

    Keywords: Myocardial Infarction, Cardiac regeneration, Lats-IN-1, Hippo pathway, cardiomyocyte proliferation, Heart Failure, Apoptosis

    Received: 11 Jul 2024; Accepted: 26 Sep 2024.

    Copyright: © 2024 Shen, Wang, Liu, Wang, Zhou, Zhang and Zhuang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Dandan Zhou, Department of Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China
    Lin Zhang, Department of Cardiovascular Surgery, PLA General Hospital, Beijing, 100853, Beijing Municipality, China
    Jinqiang Zhuang, Emergency Intensive Care Unit(EICU), The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.