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SYSTEMATIC REVIEW article

Front. Pharmacol.
Sec. Renal Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1462965
This article is part of the Research Topic Diabetic Kidney Disease: Routes to drug development, pharmacology and underlying molecular mechanisms, Volume II View all 12 articles

Incidence of Hyperkalemia RAASi and SGLT-2i Treatment in Individuals with Diabetic Kidney Disease: A Systematic Review and Network Meta-Analysis

Provisionally accepted
Yahui Yuan Yahui Yuan 1Chun Chen Chun Chen 2Yuping Lin Yuping Lin 3Lu Sun Lu Sun 3Guanjie Fan Guanjie Fan 1*
  • 1 Guangzhou University of Chinese Medicine, Guangzhou, China
  • 2 China Academy of Chinese Medical Sciences, Beijing, Beijing Municipality, China
  • 3 Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, China

The final, formatted version of the article will be published soon.

    Background: This study aims to evaluate the incidence of hyperkalemia and serum potassium levels associated with the use of sodium-glucose cotransporter-2 inhibitors (SGLT-2i), renin-angiotensin-aldosterone system inhibitors (RAASi) and concurrent use of these medications in individuals with diabetic kidney disease (DKD). Methods: A comprehensive systematic search was performed in EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, Scopus, and PubMed database, covering studies up to March 2024.

    Keywords: Diabetic kidney disease, Renin-angiotensin-aldosterone system inhibitors, Hyperkalemia, SGLT-2i, Network meta-analysis

    Received: 11 Jul 2024; Accepted: 20 Dec 2024.

    Copyright: © 2024 Yuan, Chen, Lin, Sun and Fan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Guanjie Fan, Guangzhou University of Chinese Medicine, Guangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.