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REVIEW article

Front. Pharmacol.
Sec. Integrative and Regenerative Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1462368
This article is part of the Research Topic Integrative Pharmacological Approaches for Regenerating Cartilage and Bone Tissue View all 5 articles

Metal-Organic Frameworks (MOFs) and Their Derivatives as Emerging Biomaterials for the Treatment of Osteoarthritis

Provisionally accepted
Yufu Liu Yufu Liu Hongwei Zhang Hongwei Zhang Tianyan Chen Tianyan Chen Chang Xu Chang Xu Xingfu Bao Xingfu Bao *
  • Jilin University, Changchun, China

The final, formatted version of the article will be published soon.

    As a novel class of smart biomaterials with promising potentials, metal-organic frameworks (MOFs) are widely utilized in the field of biomedicine. Current researches indicate that the therapeutic strategies for osteoarthritis (OA) are highly limited to achieving symptom improvement and reducing both pain and inflammation. Together, the introduction of MOFs into the treatment of OA holds the potential to offer significant benefits. This is because MOFs not only have intrinsic biological activities, but also act as carriers to facilitate controlled drug delivery and prolong the duration in the management of OA. This paper presents a review of the recent studies that have explored the potential usage of MOFs as drugs or carriers in the treatment of OA, which also examines the progress of MOFs in tissue engineering for the treatment of OA. These studies are anticipated to not only enhance the comprehension of MOFs but also provide strong evidence in favor of their utilization in the treatment of OA.

    Keywords: Metal-Organic Frameworks, Osteoarthritis, Biomaterials, Scaffold, bone tissue engineering

    Received: 10 Jul 2024; Accepted: 09 Sep 2024.

    Copyright: © 2024 Liu, Zhang, Chen, Xu and Bao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xingfu Bao, Jilin University, Changchun, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.