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REVIEW article

Front. Pharmacol.
Sec. Pharmacology of Ion Channels and Channelopathies
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1459683
This article is part of the Research Topic Pharmacological Perspectives into Transient Receptor Potential Channels View all articles

The Role of TRPV1 in Chronic Prostatitis: A Review

Provisionally accepted
Zhipeng Jiang Zhipeng Jiang 1,2Wen Luo Wen Luo 1,2*Zongmin Long Zongmin Long 1,2Jie Chen Jie Chen 3
  • 1 Zunyi Medical University, Zunyi, China
  • 2 First People’s Hospital of Zunyi, Zunyi, Guizhou Province, China
  • 3 Kweichou Moutai Hospital, Zunyi, Guizhou Province, China

The final, formatted version of the article will be published soon.

    Chronic prostatitis is a prevalent male urinary system disorder characterized by pelvic discomfort or pain, bladder dysfunction, sexual dysfunction, and infertility. Pain and lower urinary tract symptoms (LUTS) are the most common symptoms, significantly impacting patients' quality of life and driving them to seek medical attention. Transient receptor potential vanilloid subtype 1 (TRPV1) is a non-selective calcium ion-dependent cation channel in the TRPV channel family that is widely distributed in neural tissue and plays a role in signal transmission. In this review, we provide a comprehensive overview of the current understanding of the role of TRPV1 in chronic prostatitis.The discussion focuses on the connection between TRPV1 and prostatitis pain and LUTS, and highlights the potential for targeting this channel in the development of novel treatment strategies.

    Keywords: TRPV1 channel, Prostatitis, Pain, Lower Urinary Tract Symptoms, Therapeutic target

    Received: 04 Jul 2024; Accepted: 10 Sep 2024.

    Copyright: © 2024 Jiang, Luo, Long and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Wen Luo, Zunyi Medical University, Zunyi, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.