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REVIEW article
Front. Pharmacol.
Sec. Pharmacology of Ion Channels and Channelopathies
Volume 15 - 2024 |
doi: 10.3389/fphar.2024.1459683
This article is part of the Research Topic Pharmacological Perspectives into Transient Receptor Potential Channels View all articles
The Role of TRPV1 in Chronic Prostatitis: A Review
Provisionally accepted- 1 Zunyi Medical University, Zunyi, China
- 2 First People’s Hospital of Zunyi, Zunyi, Guizhou Province, China
- 3 Kweichou Moutai Hospital, Zunyi, Guizhou Province, China
Chronic prostatitis is a prevalent male urinary system disorder characterized by pelvic discomfort or pain, bladder dysfunction, sexual dysfunction, and infertility. Pain and lower urinary tract symptoms (LUTS) are the most common symptoms, significantly impacting patients' quality of life and driving them to seek medical attention. Transient receptor potential vanilloid subtype 1 (TRPV1) is a non-selective calcium ion-dependent cation channel in the TRPV channel family that is widely distributed in neural tissue and plays a role in signal transmission. In this review, we provide a comprehensive overview of the current understanding of the role of TRPV1 in chronic prostatitis.The discussion focuses on the connection between TRPV1 and prostatitis pain and LUTS, and highlights the potential for targeting this channel in the development of novel treatment strategies.
Keywords: TRPV1 channel, Prostatitis, Pain, Lower Urinary Tract Symptoms, Therapeutic target
Received: 04 Jul 2024; Accepted: 10 Sep 2024.
Copyright: © 2024 Jiang, Luo, Long and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wen Luo, Zunyi Medical University, Zunyi, China
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