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PERSPECTIVE article
Front. Pharmacol.
Sec. Integrative and Regenerative Pharmacology
Volume 15 - 2024 |
doi: 10.3389/fphar.2024.1458997
This article is part of the Research Topic Recent Advances in the Management of Crush Syndrome: From Bench to Bedside View all articles
Multiple Site Inflammation and Acute Kidney Injury in Crush Syndrome
Provisionally accepted- 1 School of Medicine, Keio University, Tokyo, Japan
- 2 Kyoritsu Women's University, Chiyoda, Tokyo, Tōkyō, Japan
- 3 Kyoto Pharmaceutical University, Kyoto, Tōkyō, Japan
- 4 Tokyo University of Pharmacy and Life Sciences, Hachioji, Tōkyō, Japan
Crush syndrome, which frequently occurs in earthquake disasters, often leads to rhabdomyolysis induced acute kidney injury (RIAKI). Recent findings indicate that systemic inflammatory response syndrome (SIRS) exacerbates muscle collapse, contributing to RIAKI. The purpose of this study is to investigate the involvement of multiple site inflammation, including intraperitoneal, in crush syndrome. In a mouse model of RIAKI, elevated levels of inflammatory mediators such as TNFα, IL-6, myoglobin, and dsDNA were observed in serum and the peritoneal cavity, peaking earlier in the intraperitoneal cavity than in serum or urine. Our previously developed novel peptide inhibiting leukocyte extracellular traps was administered intraperitoneally and blocked all of these mediators in the intraperitoneal cavity and serum, ameliorating muscle damage and consequent RIAKI. Although further studies are needed to determine whether intraperitoneal inflammation associated with muscle collapse can lead to systemic inflammation, resulting in more severe and prolonged muscle damage and renal injury, early suppression of multiple site inflammation, including intraperitoneal, might be an effective therapeutic target.
Keywords: Crush Syndrome, Rhabdomyolysis, kidney injury, macrophage extracellular trap, muscle damage, intraperitoneal inflammation, Systemic Inflammatory Response Syndrome
Received: 03 Jul 2024; Accepted: 08 Aug 2024.
Copyright: © 2024 Miyauchi, Okubo, Iida, Kawakami, Takayama, Hayashi, Haruta, Sasaki, Hayashi and Hirahashi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Junichi Hirahashi, School of Medicine, Keio University, Tokyo, 108-8345, Japan
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