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SYSTEMATIC REVIEW article

Front. Pharmacol.
Sec. Ethnopharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1458621
This article is part of the Research Topic Plant and Fungal Extracts and Metabolites in Neurotherapy: Exploring Their Pharmacology and Potential Clinical Uses View all articles

Plant Medicine CompoundMetabolite Yulinzhu treating Neurological Disorder Causing Polycystic Ovary Syndrome: A systematic review and a Meta-Analysis

Provisionally accepted
Beibei Jiao Beibei Jiao 1Si Chen Si Chen 1Jian Zhang Jian Zhang 1Peijuan Wang Peijuan Wang 1Weibo Zhao Weibo Zhao 2*
  • 1 Affliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Liaoning Province, China
  • 2 Wuxi Hospital Affiliated to Nanjing University of Chinese Medicine, Wuxi, China

The final, formatted version of the article will be published soon.

    Background: Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder that affects women of reproductive age, characterized by chronic anovulation, hyperandrogenism, and polycystic ovarian morphology. Emerging evidence indicates that neurological disorders play a significant role in the etiology of PCOS, highlighting the complex interplay between the central nervous system (CNS) and ovarian function. Yulinzhu, a traditional Chinese medicine (TCM) formulation, has been traditionally used to regulate menstrual cycles and improve fertility. This study aims to investigate the efficacy and mechanisms of Yulinzhu in treating PCOS induced by neurological disorders.Methods: An extensive literature search was performed across electronic databases such as PubMed, EMBASE, Cochrane Library, and CNKI, covering publications up to June 1st, 2024. The review included randomized controlled trials (RCTs) that compared Yulin Zhu with placebo, standard care, or other active treatments in patients with PCOS. Two reviewers independently carried out data extraction and quality assessment. Meta-analyses were conducted using both fixed and random-effects models, with heterogeneity evaluated using the I² statistic.We screened 891 records and included 6 studies in the meta-analysis. The meta-analysis revealed that Yulinzhu about effective rate(RR = 1.19, 95% CI [1.10, 1.29], P < 0.0001), pregnancy rate (RR = 2.80, 95% CI [1.65,4.76], P < 0.0001) and ovulation rate (RR = 1.33, 95% CI [1.10, 1.62]], P = 0.04). Meta-analysis shows the results of follicle estrogen (WMD = 0.69, 95% CI [-0.39, 1.78], P = 0.21), luteinizing hormone (WMD = -2.27, 95% CI [-3.86, -0.67], P = 0.005), testosterone (WMD = -0.44, 95% CI [-0.64, -0.25], P＜0.0001), estradiol (WMD = 16.20, 95% CI [2.74,29.67], P＜0.0001).This study demonstrates that plant medicine compund Yulinzhu can may effectively treats PCOS including hormonal regulation, anti-inflammatory actions, and neuroprotection. We expect further research with larger, well-designed clinical trials to substantiate our conclusions.

    Keywords: Polycystic Ovary Syndrome, neurological disorders, Yulinzhu, hormonal regulation, Neuroprotection

    Received: 02 Jul 2024; Accepted: 29 Jul 2024.

    Copyright: © 2024 Jiao, Chen, Zhang, Wang and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Weibo Zhao, Wuxi Hospital Affiliated to Nanjing University of Chinese Medicine, Wuxi, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.