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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Renal Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1456903

MITIGATIVE ROLE OF CYSTEAMINE AGAINST UNILATERAL RENAL REPERFUSION INJURY IN WISTAR RATS

Provisionally accepted
Babatunde A. Alabi Babatunde A. Alabi 1,2*Okot-Asi NKU-EKPANG Okot-Asi NKU-EKPANG 3Sodiq K. LAWAL Sodiq K. LAWAL 4EZEKIEL O. IWALEWA EZEKIEL O. IWALEWA 5Temidayo Omobowale Temidayo Omobowale 5Richard Ajike Richard Ajike 6Ridwan A. Lawal Ridwan A. Lawal 7
  • 1 Bowen University, Iwo, Nigeria
  • 2 Kampala International University in Tanzania, Dar es Salaam, Tanzania
  • 3 University of Calabar, Calabar, Cross River, Nigeria
  • 4 University of Botswana, Gaborone, Botswana
  • 5 University of Ibadan, Ibadan, Oyo, Nigeria
  • 6 Ladoke Akintola University of Technology, Ogbomosho, Oyo, Nigeria
  • 7 University of Lagos, Lagos, Nigeria

The final, formatted version of the article will be published soon.

    Background: Ischemia-reperfusion injury (IRI) is unavoidable during kidney transplant and it is responsible for delayed or non-function after kidney transplantation. Cysteamine is the standard drug in the management of nephropathic cystinosis and its extra-renal complications. Thus, we designed this study to investigate its potential against renal reperfusion injury.Results: Significant elevation of H2O2, MDA, and nitrite and reduced GPx, GSH, and protein thiol in the IRI rats was reversed by cysteamine (50 and 100 mg/kg). Serum MPO, TNF-α, IL-1β, creatinine, and AOPP were significantly elevated in IRI while rats treated with cysteamine revealed a significant decrease (p<0.05) in the activities of these pro-inflammatory and renal injury markers.Based on its activity against inflammation, apoptosis, and free radical-induced stress, cysteamine has great potential to be used as a kidney transplant pre-operative drug to prevent renal reperfusion injury.

    Keywords: renal injury, transcription factor, inflammatory mediators, Caspase 3, Kidney transplant

    Received: 29 Jun 2024; Accepted: 28 Aug 2024.

    Copyright: © 2024 Alabi, NKU-EKPANG, LAWAL, IWALEWA, Omobowale, Ajike and Lawal. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Babatunde A. Alabi, Bowen University, Iwo, Nigeria

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.