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SYSTEMATIC REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 15 - 2024 |
doi: 10.3389/fphar.2024.1455969
Network meta-analysis of integrated traditional Chinese and Western medicine in the treatment of Sjogren's syndrome
Provisionally accepted
Xie Li Ma
*
Liu Zixia
Tian Chang
Chuanhui Yao
*
Yuchen Yang
*
Biyue Shang
*
Jiameng Liu
*
Congmin Xia
Gong Xun
*
Quan Jiang
*- Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Abstract Objective: To evaluate efficacy and safety of traditional Chinese medicine(TCM) combined with Western medicine in treatment of Sjogren's syndrome (SS). Methods: CNKI, WanFang, VIP, CBM, Sinomed, PubMed, Embase, and Web of Science were searched to collect randomized controlled trials (RCTs) of TCM combined with conventional western medicine(CWM) in treating SS from the time of their estalishment to May 2023. The researchers independently screened the literature and extracted data for quality evaluation. Analyses were performed using Review Manager(version 5.4) and R-4.3.1. Results: A total of 66 RCTs were included, with a sample size of 5052, involving four kinds of TCM (total glucosides of paeony capsules,tripterygium glycosides tablet,Xinfeng capsule and Xinfeng capsule)and three kinds of CWM(hydroxychloroquine sulfate,Iguratimod and glucocorticoid). The network meta-analysis results showed that IGU+HCQ+TGP ranked the highest in reducing ESR and IgG and improving the Schirmer test when the three drugs were combined. When the two drugs are combined, IGU+GC and TGT+TGP are good choices for reducing erythrocyte sedimentation rate(ESR) and Immunoglobulin G(IgG). Although TGP+HCQ vs HCQ had the most studies, TGP combined with HCQ did not rank high in each outcome indicator. It is recommended to use TGT and XFG in decreasing ESR and IgG for a single drug. JJQR have an advantageous role in relieving xerostomia and dry eyes. Conclusion: TCM combined with CWM has a very significant effect on treating SS compared with CWM alone.According to the network meta-analysis, the best intervention measures of different TCMs for different outcome indicators were obtained.
Keywords: Sjogren's syndrom, Chinese patent medicine, Tripterygium wilfordii polyglycosides tablets, Total glucosides of paeony capsule, Network meta-analysis, Randomized controlled
Received: 17 Jul 2024; Accepted: 13 Nov 2024.
Copyright: © 2024 Ma, Zixia, Chang, Yao, Yang, Shang, Liu, Xia, Xun and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xie Li Ma, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Chuanhui Yao, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Yuchen Yang, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Biyue Shang, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Jiameng Liu, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Gong Xun, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Quan Jiang, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
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