AUTHOR=Maeda Kazuma , Tanimura Miki , Masago Yusaku , Horiyama Tsukasa , Takemoto Hiroshi , Sasaki Takuya , Koyama Ryuta , Ikegaya Yuji , Ogawa Koichi TITLE=Development of an in vitro compound screening system that replicate the in vivo spine phenotype of idiopathic ASD model mice JOURNAL=Frontiers in Pharmacology VOLUME=15 YEAR=2024 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1455812 DOI=10.3389/fphar.2024.1455812 ISSN=1663-9812 ABSTRACT=
Autism Spectrum Disorder (ASD) is a developmental condition characterized by core symptoms including social difficulties, repetitive behaviors, and sensory abnormalities. Aberrant morphology of dendritic spines within the cortex has been documented in genetic disorders associated with ASD and ASD-like traits. We hypothesized that compounds that ameliorate abnormalities in spine dynamics might have the potential to ameliorate core symptoms of ASD. Because the morphology of the spine is influenced by signal inputs from other neurons and various molecular interactions, conventional single-molecule targeted drug discovery methods may not suffice in identifying compounds capable of ameliorating spine morphology abnormalities. In this study, we focused on spine phenotypes in the cortex using BTBR