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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1454713
This article is part of the Research Topic The Pharmacological Effects and Mechanisms of Drugs Against Human Diseases by Modulating Redox Homeostasis - Volume II View all articles

D-mannose reduces oxidative stress, inhibits inflammation, and increases Treg cell proportions in mice with ulcerative colitis

Provisionally accepted
Yuqing Lu Yuqing Lu 1*Yongjian Xiong Yongjian Xiong 2Shuangshuang Zhang Shuangshuang Zhang 1*Boya Wang Boya Wang 1*Yuntao Feng Yuntao Feng 3Zhuonan Pu Zhuonan Pu 4Kun Wei Kun Wei 1*Jun Chen Jun Chen 1*Dapeng Chen Dapeng Chen 1*Peng Zhang Peng Zhang 5*
  • 1 Comparative Medicine Department of Researching and Teaching, Dalian Medical University, 116044 Dalian City, Liaoning Province, China
  • 2 Central Laboratory, First Affiliated Hospital of Dalian Medical University, Dalian, China
  • 3 Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China
  • 4 Beijing Neurosurgical Institute, Capital Medical University, Beijing, China
  • 5 Department of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, China

The final, formatted version of the article will be published soon.

    Regulatory T (Treg) cells is required to dampen immune responses against intestinal microbiota, which aid in a healthy body to promise that the resident gut microbiota should not attract the attention of the immune system. Inflammation and inflammatory bowel disease (IBD) can be induced if the immune system fails to ignore the resident gut microbiota and targets them instead. D-mannose, a common monosaccharide in nature, has been shown to ameliorate multiple autoimmune diseases. This study aimed to investigate the therapeutic effect of D-mannose on mice ulcerative colitis (UC) induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS), and elucidate its underlying mechanisms. Our results demonstrated that D-mannose treatment effectively alleviated TNBS-induced UC in mice, as evidenced by the amelioration of UC symptoms. D-mannose treatment significantly reduced inflammation by decreasing the expression of proinflammatory cytokines and inflammation mediators. D-mannose treatment also significantly inhibited oxidative stress, promoted the expression of GSH and SOD, decreased the expression of MDA. Mechanistically, D-mannose upregulated the proportion of both CD4(+) Tregs and CD8(+) Tregs. In summary, our study provides the first evidence of the therapeutic effect of D-mannose on mice with UC, which is likely mediated by upregulating Treg proportions.

    Keywords: regulatory T cells, Oxidative Stress, Infalmmatory bowel disease, d-mannose, intestinal immunity

    Received: 25 Jun 2024; Accepted: 18 Oct 2024.

    Copyright: © 2024 Lu, Xiong, Zhang, Wang, Feng, Pu, Wei, Chen, Chen and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yuqing Lu, Comparative Medicine Department of Researching and Teaching, Dalian Medical University, 116044 Dalian City, Liaoning Province, China
    Shuangshuang Zhang, Comparative Medicine Department of Researching and Teaching, Dalian Medical University, 116044 Dalian City, Liaoning Province, China
    Boya Wang, Comparative Medicine Department of Researching and Teaching, Dalian Medical University, 116044 Dalian City, Liaoning Province, China
    Kun Wei, Comparative Medicine Department of Researching and Teaching, Dalian Medical University, 116044 Dalian City, Liaoning Province, China
    Jun Chen, Comparative Medicine Department of Researching and Teaching, Dalian Medical University, 116044 Dalian City, Liaoning Province, China
    Dapeng Chen, Comparative Medicine Department of Researching and Teaching, Dalian Medical University, 116044 Dalian City, Liaoning Province, China
    Peng Zhang, Department of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, China

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