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REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 15 - 2024 |
doi: 10.3389/fphar.2024.1454348
This article is part of the Research Topic Efficacy and Mechanism of Herbal Medicines and Their Functional Compounds in Preventing and Treating Cardiovascular Diseases and Cardiovascular Disease Risk Factors - Volume II View all 10 articles
Oxylipins as Therapeutic Indicators of Herbal Medicines in Cardiovascular Diseases: A Review
Provisionally accepted
Mengqi Li
1
Min He
2
Mengmeng Sun
2*
Yongping Li
3*
Mengyuan Li
2
Xiaobo Jiang
1*
Yanxin Wang
4*
Hongfeng Wang
2*- 1 College of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, China
- 2 Northeast Asia Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China
- 3 Changchun Sino-Russian Science and Technology Park Co., Ltd., Changchun, China
- 4 Department of Cardiovascular Rehabilitation, The Third Affiliated Clinical Hospital of Changchun University of Traditional Chinese Medicine, Jilin, China
Globally, cardiovascular diseases (CVDs) remain the leading cause of death, and their prevention and treatment continue to face major challenges. Oxylipins, as novel circulating markers of cardiovascular disease, are crucial mediators linking cardiovascular risk factors such as inflammation and platelet activation, and they play an important role in unraveling cardiovascular pathogenesis and therapeutic mechanisms. Chinese herbal medicine plays an important role in the adjuvant treatment of cardiovascular diseases, which has predominantly focused on the key pathways of classic lipids, inflammation, and oxidative stress to elucidate the therapeutic mechanisms of cardiovascular diseases. However,The regulatory effect of traditional Chinese medicine on oxylipins in cardiovascular diseases remains largely unknown. With the increasing number of recent reports on the regulation of oxylipins by Chinese herbal medicine in cardiovascular diseases, it is necessary to comprehensively elucidate the regulatory role of Chinese herbal medicine in cardiovascular diseases from the perspective of oxylipins. This approach not only benefits further research on the therapeutic targets of Chinese herbal medicine, but also brings new perspectives to the treatment of cardiovascular diseases.
Keywords: Herbal Medicine, cardiovascular disease, polyunsaturated fatty acids, Oxylipins, review
Received: 25 Jun 2024; Accepted: 03 Dec 2024.
Copyright: © 2024 Li, He, Sun, Li, Li, Jiang, Wang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Mengmeng Sun, Northeast Asia Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China
Yongping Li, Changchun Sino-Russian Science and Technology Park Co., Ltd., Changchun, China
Xiaobo Jiang, College of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, China
Yanxin Wang, Department of Cardiovascular Rehabilitation, The Third Affiliated Clinical Hospital of Changchun University of Traditional Chinese Medicine, Jilin, China
Hongfeng Wang, Northeast Asia Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China
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