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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Ethnopharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1452989
This article is part of the Research Topic Targeting Neuroinflammation for Novel Therapeutics in Neurodegenerative Diseases View all 8 articles

Polydatin attenuated neuropathic pain and motor dysfunction following spinal cord injury in rats by employing its anti-inflammatory and antioxidant effects

Provisionally accepted
Faezeh S. Bavandpuri Faezeh S. Bavandpuri 1Atefeh Azizi Atefeh Azizi 1Fatemeh Abbaszadeh Fatemeh Abbaszadeh 2Amir Kiani Amir Kiani 3,4Mohammad H. Farzaei Mohammad H. Farzaei 3Ehsan Mohammadi-Noori Ehsan Mohammadi-Noori 3Sajad Fakhri Sajad Fakhri 3*Javier Echeverria Javier Echeverria 5*
  • 1 Student Research Committee, Kermanshah university of Medical Sciences, Kermansha, Iran
  • 2 Neurobiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Alborz, Iran
  • 3 Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Kerman, Iran
  • 4 Regenerative Medicine Research Center, Kermanshah University of Medical Sciences, Kermanshah, Kerman, Iran
  • 5 Departamento de Ciencias del Ambiente, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Santiago Metropolitan Region (RM), Chile

The final, formatted version of the article will be published soon.

    Background: Considering the complex pathological mechanisms behind spinal cord injury (SCI) and the adverse effects of present non-approved drugs against SCI, new studies are needed to introduce novel multi-target active ingredients with higher efficacy and lower side effects.Polydatin (PLD) is a naturally occurring stilbenoid glucoside recognized for its antioxidative and anti-inflammatory properties. This study aimed to assess the effects of PLD on sensory-motor function following SCI in rats.Methods: Following laminectomy and clip compression injury at the thoracic 8 (T8)-T9 level of the spinal cord, rats were randomly assigned to five groups: Sham, SCI, and three groups receiving different doses of PLD treatment (1, 2, and 3 mg/kg). Over four weeks, behavioral tests were done such as von Frey, acetone drop, hot plate, Basso-Beattie-Bresnahan, and inclined plane, along with weight measurements. At the end of the study, changes in catalase and glutathione activity, nitrite level, activity of matrix metalloproteinase 2 (MMP2) and MMP9 as well as spinal tissue remyelination/neurogenesis, were evaluated.The results revealed that PLD treatment significantly improved the behavioral performance and weight of the animals starting from the first week after SCI. Additionally, PLD increased catalase, and glutathione levels, and MMP2 activity while reduced serum nitrite levels and MMP9. These positive effects were accompanied by a reduction in the size of the lesion and preservation of neuronal count.In conclusion, PLD showed neuroprotective effects in SCI rats by employing antiinflammatory and antioxidant effects, through which improve sensory and motor function.

    Keywords: spinal cord injury, Polydatin, Oxidative Stress, Inflammation, Motor Activity, neuropathic pain

    Received: 21 Jun 2024; Accepted: 31 Jul 2024.

    Copyright: © 2024 Bavandpuri, Azizi, Abbaszadeh, Kiani, Farzaei, Mohammadi-Noori, Fakhri and Echeverria. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Sajad Fakhri, Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Kerman, Iran
    Javier Echeverria, Departamento de Ciencias del Ambiente, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Santiago Metropolitan Region (RM), Chile

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.