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SYSTEMATIC REVIEW article

Front. Pharmacol.
Sec. Neuropharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1452614

Multi-omics Approaches to Deciphering Complex Pathological Mechanisms of Migraine: A systematic review

Provisionally accepted
Jiaojiao Liu Jiaojiao Liu Qiaosheng Ren Qiaosheng Ren Boxuan Du Boxuan Du Xian Liu Xian Liu Yuqiu An Yuqiu An Peichi Zhang Peichi Zhang Lexi Li Lexi Li Zhenhong Liu Zhenhong Liu *Kegang Cao Kegang Cao *
  • Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China

The final, formatted version of the article will be published soon.

    Background: Migraine represents a chronic neurological disorder characterized by high prevalence, substantial disability rates, and significant economic burden. Its pathogenesis is complex, and there is currently no cure. The rapid progress in multi-omics technologies has provided new tools to uncover the intricate pathological mechanisms underlying migraine. This systematic review aims to synthesize the findings of multi-omics studies on migraine to further elucidate the complex mechanisms of disease onset, thereby laying a scientific foundation for identifying new therapeutic targets.We conducted a comprehensive systematic review, specifically focusing on clinical observational studies that investigate various aspects of migraine through the integration of genomics, transcriptomics, proteomics, and metabolomics. Our search encompassed multiple databases including PubMed, EMBASE, the Web of Science Core Collection, the Cochrane Library, China National Knowledge Infrastructure, the Chinese Science and Technology Periodical Database, the Wanfang database, and the China Biology Medicine Database to cover studies from database inception until March 20th, 2024., The scope of our review included various aspects of migraine such as ictal and interictal phases; episodic or chronic migraine; menstrualrelated migraine; and migraine with or without aura (PROSPERO registration number:Results: A total of 38 studies were ultimately included, highlighting a range of genetic variations, transcriptional abnormalities, protein function alterations, and disruptions in metabolic pathways associated with migraine.These multi-omics findings underscore the pivotal roles played by mitochondrial dysfunction, inflammatory responses, and oxidative stress in the pathophysiology of migraine.Multi-omics approaches provide novel perspectives and tools for comprehending the intricate pathophysiology of migraine, facilitating the identification of potential biomarkers and therapeutic targets.

    Keywords: H, Healthy Control Group, MICP, Migraine Ictal Phase, MINP, Migraine Interictal Phase, MA,migraine with aura, MO, Migraine without aura, CM,chronic migraine, MM, menstrualrelated migraine, CSF, Cerebral spinal fluid

    Received: 21 Jun 2024; Accepted: 23 Dec 2024.

    Copyright: © 2024 Liu, Ren, Du, Liu, An, Zhang, Li, Liu and Cao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zhenhong Liu, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China
    Kegang Cao, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.