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REVIEW article

Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1452276

Pathologic function and therapeutic potential of extracellular vesicle miRNA in sepsis

Provisionally accepted
Rou Deng Rou Deng 1,2Xiayu Cui Xiayu Cui 3Runze Zhang Runze Zhang 1,2Changya Liu Changya Liu 1,2Jielian Luo Jielian Luo 1,2Liang Liu Liang Liu 1,2Wen Zhang Wen Zhang 1,3*Bangjiang Fang Bangjiang Fang 1,2*
  • 1 Department of Emergency, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
  • 2 Shanghai University of Traditional Chinese Medicine, Shanghai, Shanghai Municipality, China
  • 3 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China

The final, formatted version of the article will be published soon.

    Sepsis is a systemic inflammatory response initiated by an infection, which can lead to multi-organ dysfunction. The pathophysiology of sepsis is complex, and treatment options are limited. Traditional antibiotic therapies have shown limitations, such as promoting the emergence of antibiotic-resistant bacteria and disrupting the natural microbiota. Consequently, there is a pressing need to explore diverse therapeutic approaches for sepsis management. Extracellular vesicles, which play a crucial role in cell-to-cell communication, are released by various cell types throughout the body and possess a membrane structure composed of a lipid bilayer.MicroRNAs may be encapsulated within these structures and can be selectively delivered to target recipient cells through the activation of cell surface receptors or via endocytosis and fusion, thereby modulating the biological functions of target cells.The article examines the pathological alterations that happen as sepsis progresses and the biological control of extracellular vesicles and microRNAs in sepsis. This review focuses on the role of extracellular vesicles and their microRNAs on controlling the inflammatory response, macrophage polarization, programmed cell death, endothelial dysfunction, and microcirculatory changes in sepsis. Furthermore, the obstacles encountered by this novel therapy are also examined.

    Keywords: Extracellular vesicle, microRNA, Sepsis, programmed cell death, inflammation, endothelial dysfunction, therapy, diagnosis

    Received: 20 Jun 2024; Accepted: 04 Nov 2024.

    Copyright: © 2024 Deng, Cui, Zhang, Liu, Luo, Liu, Zhang and Fang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Wen Zhang, Department of Emergency, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    Bangjiang Fang, Department of Emergency, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.