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SYSTEMATIC REVIEW article

Front. Pharmacol.
Sec. Drugs Outcomes Research and Policies
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1450120
This article is part of the Research Topic Clinical Pharmacist Service Promotes the Improvement of Medical Quality Volume II View all 24 articles

Factors affecting posaconazole plasma concentrations: A metaanalysis and systematic review

Provisionally accepted
Ruochen Qu Ruochen Qu 1Yan Liu Yan Liu 1Yan Zhao Yan Zhao 1Ziyi Wang Ziyi Wang 1Shizhao Yuan Shizhao Yuan 2Shuai Liu Shuai Liu 2Jing Yu Jing Yu 1*
  • 1 The First hospital of Hebei Medical University, Shijiazhuang, China
  • 2 Hebei Medical University, Shijiazhuang, Hebei Province, China

The final, formatted version of the article will be published soon.

    This manuscript investigates the factors that influence the concentration of different posaconazole formulations. We systematically searched PubMed, EMBASE, and the Cochrane Library to identify studies assessing factors that influence blood posaconazole concentrations. We included 46 studies involving 8,505 patients. Co-administration of drugs affecting posaconazole metabolism significantly reduces its concentrations. High-fat nutrition, age, and sex did not significantly influence posaconazole oral suspension (POS) concentrations. Diarrhea markedly reduced concentrations in both delayed-release tablets (DRT) and POS. Neither vomiting nor mucositis significantly affected POS concentrations. Acid-suppressing agents such as H2 receptor antagonists and proton pump inhibitors markedly decreased POS concentrations but did not affect DRT. Comparative studies of dosage forms demonstrated significantly higher concentrations in DRT than in POS. This study discusses changes in posaconazole concentrations in a variety of patients and dosing conditions. I am confident that this manuscript meets the high standards of scientific rigor and originality expected by the Frontiers in Pharmacology.

    Keywords: Data curation, Validation, Writing -original draft. Ruochen Qu: Data curation, investigation, Software, visualization, Writing -original draft. Shuai Liu: Data curation, methodology

    Received: 17 Jun 2024; Accepted: 28 Nov 2024.

    Copyright: © 2024 Qu, Liu, Zhao, Wang, Yuan, Liu and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jing Yu, The First hospital of Hebei Medical University, Shijiazhuang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.