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ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Gastrointestinal and Hepatic Pharmacology
Volume 15 - 2024 |
doi: 10.3389/fphar.2024.1447970
This article is part of the Research Topic Targeting the Tumor Microenvironment for Effective Treatment of Gastrointestinal Cancers View all 4 articles
Unraveling the regulatory cell death pathways in gastric cancer: A multi-omics study
Provisionally accepted- 1 Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- 2 Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China
Gastric cancer (GC) is a prevalent form of cancer worldwide and has a high death rate, with less than 40% of patients surviving for 5 years. GC demonstrates a vital characteristic of evading regulatory cell death (RCD). However, the extent to which RCD patterns are clinically significant in GC has not been well investigated. The study created a regulatory cell death index (RCDI) signature by employing 101 machine-learning algorithms. These algorithms were based on the expression files of 1292 GC patients from 6 multicenter cohorts.RCDI is a reliable and robust determinant of the likelihood of surviving in general.Furthermore, the precision of RCDI surpasses that of the 20 signatures that have been previously disclosed. The presence of RCDI signature is closely linked to immunological characteristics, such as the infiltration of immune cells, the presence of immunotherapy markers, and the activation of immune-related functions. This suggests that there is a higher level of immune activity in cases with RCDI signature. Collectively, the use of RCDI has the potential to be a strong and encouraging method for enhancing the clinical results of individual individuals with GC.
Keywords: gastric cancer, Regulatory cell death, immune microenvironment, Prognostic signature, Immunotherapy
Received: 12 Jun 2024; Accepted: 26 Aug 2024.
Copyright: © 2024 Sun, Rao, Zhou, Zeng and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Lixiang Rao, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Yulan Zeng, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Yalu Sun, Affiliated Hospital of Jining Medical University, Jining, 272000, Shandong Province, China
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