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REVIEW article

Front. Pharmacol.
Sec. Ethnopharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1447097
This article is part of the Research Topic Natural Products for the Treatment of Respiratory Disorders View all 5 articles

Natural products for the treatment of allergic rhinitis: Focus on cellular signaling pathways and pharmacological targets

Provisionally accepted
Shabnam Moradi Shabnam Moradi 1Hosna Khazaei Hosna Khazaei 1Mitra Tarlan Mitra Tarlan 1Seyed V. Jasemi Seyed V. Jasemi 2Dr. Tanuj Joshi Dr. Tanuj Joshi 3Ina Y. Aneva Ina Y. Aneva 4Mohammad Hosein Farzaei Mohammad Hosein Farzaei 1Javier Echeverria Javier Echeverria 5*
  • 1 Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Kerman, Iran
  • 2 Department of Internal Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran, kermanshah, Iran
  • 3 Department of Pharmaceutical Sciences, Faculty of Technology, Kumaun University, Bhimtal (Nainital), Uttarakhand, India
  • 4 Institute of Biodiversity and Ecosystem Research, Bulgarian Academy of Sciences, Sofia, Sofia City, Bulgaria
  • 5 Departamento de Ciencias del Ambiente, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Santiago Metropolitan Region (RM), Chile

The final, formatted version of the article will be published soon.

    Background: Allergic rhinitis is an inflammatory disease dependent on immunoglobulin E and causes inflammation of the nasal mucosa, leading to decreased quality of life for affected patients.Since common treatments, including corticosteroids and antihistamines, have temporary therapeutic effects and numerous side effects, investigating natural compounds effective in improving allergic rhinitis with low complications and high efficacy can be significant and necessary.Purpose: This study aims to present a comprehensive and critical evaluation of the effect of natural compounds in improving allergic rhinitis.Methods: Studies were identified through systematic searches of ScienceDirect, PubMed, Scopus, and Web of Sciences databases. Eligibility checks were conducted based on predefined selection criteria. Forty-six articles were included in this study.Results and Discussion: Phytochemicals, including flavonoids, alkaloids, terpenoids, and other compounds showed significant anti-inflammatory and antihistaminic effects. These compounds alleviate allergic rhinitis symptoms by inhibiting inflammatory mediators, oxidative stress, apoptosis, and key signaling pathways such as MAPK/NFκB and TLR4/MyD88/NF-κB.Conclusions: Phytochemicals exhibit anti-inflammatory and antioxidant properties, making them promising adjuncts in allergic rhinitis treatment. Compared to traditional therapies, natural compounds offer a safer, multi-targeted approach with fewer side effects, improving patient outcomes.

    Keywords: allergic rhinitis, phytochemicals, Antioxidants, anti-inflammatory, Signaling Pathways, Pharmacological Targets

    Received: 11 Jun 2024; Accepted: 09 Sep 2024.

    Copyright: © 2024 Moradi, Khazaei, Tarlan, Jasemi, Joshi, Aneva, Farzaei and Echeverria. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Javier Echeverria, Departamento de Ciencias del Ambiente, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Santiago Metropolitan Region (RM), Chile

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.