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ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Renal Pharmacology
Volume 15 - 2024 |
doi: 10.3389/fphar.2024.1446774
An Investigation into the Correlation between Intraperitoneal Teicoplanin concentrations and Treatment Outcomes in Peritoneal Dialysis-associated Peritonitis
Provisionally accepted- 1 Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China
- 2 Department of Pharmacy, Nanjing Drum Tower Hospital, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China
- 3 Department of Nephrology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
- 4 Department of Stomatology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nangjing University, Nangjing, China
Peritoneal dialysis-associated peritonitis (PDAP) is a frequent complication of peritoneal dialysis. The guidelines from the International Society for Peritoneal Dialysis (ISPD) suggest administering teicoplanin through the peritoneal route to treat PDAP, but do not specify the ideal concentration for peritoneal dialysis effluent (PDE). Patients meeting the trial criteria for PDAP in our hospital between July 2022 and December 2023 were enrolled. Data on PDE white blood cell count, PDE neutrophil percentage, clinical symptoms, CRP, and PCT were gathered pre-and post-treatment. Incidences of ADR and case numbers during treatment were recorded. Subsequently, PDAP patients who use intraperitoneal teicoplanin could effectively control infection by considering the PDE teicoplanin concentration (> 15.138 mg/L) on day 5 after dosing.
Keywords: Peritoneal dialysis-associated peritonitis, Teicoplanin, Peritoneal dialysis effluent, Therapeutic drug monitoring, Individualized drug therapy
Received: 10 Jun 2024; Accepted: 29 Aug 2024.
Copyright: © 2024 Wang, Fan, Chen, Lei, Jiang, Liu, Yang and Shen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jiangqing Fan, Department of Pharmacy, Nanjing Drum Tower Hospital, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China
Wenpu Lei, Department of Pharmacy, Nanjing Drum Tower Hospital, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China
Chunming Jiang, Department of Nephrology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
Hang Liu, Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China
Yun Yang, Department of Stomatology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nangjing University, Nangjing, China
Jizhong Shen, Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China
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