Skip to main content

SYSTEMATIC REVIEW article

Front. Pharmacol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1445037
This article is part of the Research Topic Ovarian Cancer Targeted Medication: PARP Inhibitors, Anti-Angiogenic Drugs, Immunotherapy, and More – Volume II View all 18 articles

Mapping and visualization of global research progress on deubiquitinases in ovarian cancer: A bibliometric analysis

Provisionally accepted
Fang Qiu Fang Qiu 1Yuntong Li Yuntong Li 2*Lile Zhou Lile Zhou 1*YINGLI WU YINGLI WU 3Yunzhao Wu Yunzhao Wu 4*Zhilei Fan Zhilei Fan 5Yingying Wang Yingying Wang 3*Dongjun Qin Dongjun Qin 3*Chaoqun Li Chaoqun Li 6*
  • 1 Shenzhen Longhua District Central Hospital, Shenzhen, China
  • 2 Faculty of Geosciences and Environmental Engineering, Southwest Jiaotong University, Chengdu, Sichuan Province, China
  • 3 Hongqiao International Medical Research Institute, Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
  • 4 University of Cambridge, Cambridge, England, United Kingdom
  • 5 School of Public Health, Fudan University, Shanghai, Shanghai Municipality, China
  • 6 Department of Tropical Diseases, Naval Medical University, Shanghai, Shanghai Municipality, China

The final, formatted version of the article will be published soon.

    Background: Ovarian cancer is a highly aggressive malignancy with limited therapeutic options and a poor prognosis. Deubiquitinating enzymes (DUBs) have emerged as critical regulators of protein ubiquitination and proteasomal degradation, influencing various cellular processes relevant to cancer pathogenesis. This study mapped and visualized the research progress between ovarian cancer and DUBs using bibliometrics, and summarized the expression patterns and biological roles of DUBs in ovarian cancer. Methods: Studies related to DUBs in ovarian cancer were extracted from the Web of Science Core Collection (WoSCC) database. VOSviewer 1.6.20, CiteSpace 6.3.R1, and R4.3.3 were used for bibliometric analysis and visualization. Results: This study included 243 articles for analysis. The number of publications on DUBs in ovarian cancer has gradually increased each year. China, the United States and the United Kingdom are at the center of this field of research. The Johns Hopkins University, Genentech, and Roche Holding are the main research institutions. David Komander, Zhihua Liu and Richard Roden are top authors in this field. The top five journals with the largest publication volumes in this field are Biochemical and Biophysical Research Communications, Journal of Biological Chemistry, PLoSOne, Nature Communications and Oncotarget. Keywords burst analysis identified five research areas: "deubiquitinating enzyme," "expression," "activation," "degradation," and "ubiquitin." In addition, we summarized the expression profiles and biological roles of DUBs in ovarian cancer, highlighting their roles in tumor initiation, growth, chemoresistance and metastasis.This study provides an overview of the research progress on DUBs in ovarian cancer over the last three decades. It offers insight into the most cited papers and authors, core journals and identified new trends.

    Keywords: ovarian cancer, deubiquitinating enzyme, bibliometric analysis, biologic role, Systematic review

    Received: 06 Jun 2024; Accepted: 27 Aug 2024.

    Copyright: © 2024 Qiu, Li, Zhou, WU, Wu, Fan, Wang, Qin and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yuntong Li, Faculty of Geosciences and Environmental Engineering, Southwest Jiaotong University, Chengdu, 611756, Sichuan Province, China
    Lile Zhou, Shenzhen Longhua District Central Hospital, Shenzhen, China
    Yunzhao Wu, University of Cambridge, Cambridge, CB2 1TN, England, United Kingdom
    Yingying Wang, Hongqiao International Medical Research Institute, Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200336, China
    Dongjun Qin, Hongqiao International Medical Research Institute, Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200336, China
    Chaoqun Li, Department of Tropical Diseases, Naval Medical University, Shanghai, Shanghai Municipality, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.