AUTHOR=Belay Wubetu Yihunie , Getachew Melese , Tegegne Bantayehu Addis , Teffera Zigale Hibstu , Dagne Abebe , Zeleke Tirsit Ketsela , Abebe Rahel Belete , Gedif Abebaw Abie , Fenta Abebe , Yirdaw Getasew , Tilahun Adane , Aschale Yibeltal TITLE=Mechanism of antibacterial resistance, strategies and next-generation antimicrobials to contain antimicrobial resistance: a review JOURNAL=Frontiers in Pharmacology VOLUME=15 YEAR=2024 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1444781 DOI=10.3389/fphar.2024.1444781 ISSN=1663-9812 ABSTRACT=

Antibacterial drug resistance poses a significant challenge to modern healthcare systems, threatening our ability to effectively treat bacterial infections. This review aims to provide a comprehensive overview of the types and mechanisms of antibacterial drug resistance. To achieve this aim, a thorough literature search was conducted to identify key studies and reviews on antibacterial resistance mechanisms, strategies and next-generation antimicrobials to contain antimicrobial resistance. In this review, types of resistance and major mechanisms of antibacterial resistance with examples including target site modifications, decreased influx, increased efflux pumps, and enzymatic inactivation of antibacterials has been discussed. Moreover, biofilm formation, and horizontal gene transfer methods has also been included. Furthermore, measures (interventions) taken to control antimicrobial resistance and next-generation antimicrobials have been discussed in detail. Overall, this review provides valuable insights into the diverse mechanisms employed by bacteria to resist the effects of antibacterial drugs, with the aim of informing future research and guiding antimicrobial stewardship efforts.