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MINI REVIEW article

Front. Pharmacol.
Sec. Integrative and Regenerative Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1444653
This article is part of the Research Topic Cell Cycle Modulators: Regulating the Basic Unit of Life for Disease Treatment and Tissue Regeneration View all 5 articles

Roles of MMP-2 and MMP-9 and their associated molecules in the pathogenesis of keloids: a comprehensive review.

Provisionally accepted
Yajie Wang Yajie Wang 1Liying Zheng Liying Zheng 2Lai Zhang Lai Zhang 1Yuncheng Tai Yuncheng Tai 1Xuesong Lin Xuesong Lin 1Zhencheng Cai Zhencheng Cai 1*
  • 1 Taizhou University, Taizhou, Zhejiang Province, China
  • 2 Gannan Medical University, Ganzhou, Jiangxi Province, China

The final, formatted version of the article will be published soon.

    Keloid scars (keloids), a classical type of abnormal scar tissue formation, remain a therapeutic challenge in the field of dermatology and plastic surgery due to the unsatisfactory treatment outcomes. Keloid scars (keloids), a prototypical form of aberrant scar tissue formation, continue to pose a significant therapeutic challenge within dermatology and plastic surgery due to suboptimal treatment outcomes.Gelatinases are a subgroup of matrix metalloproteinases (MMPs), a family of enzymes that play an important role in the degradation and remodeling of the ECM (a pivotal factor for keloids development). Gelatinases include gelatinase A (MMP-2) and gelatinase B (MMP-9). Since accumulating evidence has shown that gelatinases played a crucial role in the process of keloid formation, we summarized the current knowledge on the association between MMP-2 and MMP-9 expression and the pathological process of keloids through a comprehensive review. This review demonstrated that the interplay between MMP-2, MMP-9, and their regulators, such as TGF-β1/Smad, PI3K/AKT, and LncRNA-ZNF252P-AS1/miR-15b-5p/BTF3 signaling cascades, involved in the intricate balance governing ECM homeostasis, collectively driving the excessive collagen deposition and altered tissue architecture observed in keloids. In summary, this review consolidates the current understanding of MMP-2 and MMP-9 in keloid pathogenesis, shedding light on their intricate involvement in the dysregulated keloids processes. The potential for targeted therapeutic interventions offers presents promising avenues opportunities for advancing keloid management strategies.

    Keywords: Keloids, Gelatinases, MMP-2, MMP-9, molecular mechanism

    Received: 06 Jun 2024; Accepted: 12 Nov 2024.

    Copyright: © 2024 Wang, Zheng, Zhang, Tai, Lin and Cai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhencheng Cai, Taizhou University, Taizhou, 317000, Zhejiang Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.