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REVIEW article

Front. Pharmacol.
Sec. Cardiovascular and Smooth Muscle Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1442086
This article is part of the Research Topic Cardiometabolic Diseases: Therapeutic Targets Discovery and Mechanism Study View all 4 articles

Cross-talks between Perivascular Adipose Tissue and Neighbors: multifaceted nature of Nereids

Provisionally accepted
Yujuan Li Yujuan Li 1,2,3Zhang Chen Zhang Chen 1,2,3Ying Xiao Ying Xiao 4Xinzhi Li Xinzhi Li 1,2,3*
  • 1 School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Taipa, China
  • 2 (R & D Center) Lab. for Drug Discovery from Natural Resource, Macau University of Science and Technology, Macau, China
  • 3 State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China
  • 4 Faculty of Medicine, Macau University of Science and Technology, Macau, China

The final, formatted version of the article will be published soon.

    Perivascular adipose tissue (PVAT) is a unique fat depot surrounding blood vessels and plays a vital role in the progression of vascular remodeling and dysfunction. PVAT exhibits remarkable differences in structure, phenotype, origin, and secretome across anatomical locations. The proximity of PVAT to neighboring vascular beds favors a niche for bidirectional communication between adipocytes and vascular smooth muscle cells, endothelial cells, and immune cells. In this review, we update our understanding of PVAT's regional differences and provide a comprehensive exploration of how these differences impact cross-talks between PVAT and the vascular wall. Different PVAT depots show different degrees of vasoprotective function and resilience to pathological changes such as obesity and vasculopathies, shaping multifaceted interactions between PVAT depots and adjacent vasculatures. The depot-specific resilience may lead to innovative strategies to manage cardiometabolic disorders.

    Keywords: perivascular adipose tissue, Secretome, intercellular communication, Obesity, cardiovascular disease

    Received: 01 Jun 2024; Accepted: 24 Jul 2024.

    Copyright: © 2024 Li, Chen, Xiao and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xinzhi Li, School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Taipa, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.