AUTHOR=Han Jiyu , Ma Hairong , Ai Songtao , Wan Daqian 

TITLE=Mn-ZIF nanozymes kill tumors by generating hydroxyl radical as well as reversing the tumor microenvironment

JOURNAL=Frontiers in Pharmacology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1441818

DOI=10.3389/fphar.2024.1441818

ISSN=1663-9812

ABSTRACT=<p>Tumor tissues are well known for their unique high hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) microenvironment. How to exploit this tumor microenvironment for tumor cell killing is a question. In this study, a Mn-doped metal-organic framework (Mn-ZIF) was constructed. It possesses good peroxidase (POD) activity, which can oxidize tumor-localized H<sub>2</sub>O<sub>2</sub> into hydroxyl radicals (·OH), that possesses the ability to directly kill tumor cells. More surprisingly, <italic>in vivo</italic> experiments the researchers not only observed the tumor-killing effect of Mn-ZIF, but also found it changes in macrophage phenotype in the tumor region. There was an increase in macrophage polarization towards the M1 subtype. This suggests that the tumor-killing effect of Mn-ZIF not only comes from its POD activity, but also regulates the immune microenvironment in the tumor region. In conclusion, the preparation of Mn-ZIF provides a new way for comprehensive tumor therapy.</p>