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CORRECTION article

Front. Pharmacol., 18 June 2024
Sec. Inflammation Pharmacology
Volume 15 - 2024 | https://doi.org/10.3389/fphar.2024.1441203

Corrigendum: Oral ultramicronized palmitoylethanolamide: plasma and tissue levels and spinal antihyperalgesic effect

This article is a correction to:

  1. Oral Ultramicronized Palmitoylethanolamide: Plasma and Tissue Levels and Spinal Anti-hyperalgesic Effect

    1. Read original article
Stefania Petrosino, &#x;Stefania Petrosino1,2*†Marika Cordaro&#x;Marika Cordaro3†Roberta VerdeRoberta Verde1Aniello Schiano Moriello,Aniello Schiano Moriello1,2Gabriele MarcolongoGabriele Marcolongo2Carlo SchievanoCarlo Schievano4Rosalba SiracusaRosalba Siracusa3Fabiana PiscitelliFabiana Piscitelli1Alessio F. PeritoreAlessio F. Peritore1Rosalia CrupiRosalia Crupi3Daniela ImpellizzeriDaniela Impellizzeri3Emanuela EspositoEmanuela Esposito3Salvatore CuzzocreaSalvatore Cuzzocrea3Vincenzo Di MarzoVincenzo Di Marzo1
  • 1Endocannabinoid Research Group, Institute of Biomolecular Chemistry, CNR, Napoli, Italy
  • 2Epitech Group SpA, Padova, Italy
  • 3Department of Chemical, Biological, Pharmaceutical and Environmental Science University of Messina, Messina, Italy
  • 4Innovative Statistical Research SRL, Padova, Italy

A Corrigendum on
Oral ultramicronized palmitoylethanolamide: plasma and tissue levels and spinal antihyperalgesic effect

by Petrosino S, Cordaro M, Verde R, Schiano Moriello A, Marcolongo G, Schievano C, Siracusa R, Piscitelli F, Peritore AF, Crupi R, Impellizzeri D, Esposito E, Cuzzocrea S and Di Marzo V (2018). Front. Pharmacol. 9:249. doi: 10.3389/fphar.2018.00249

In the published article, there was a problem in Figure 9B as published. As a result, we have provided another representative image from our database, belonging to the antibody in question. The corrected Figure 9 and its caption appear below.

Figure 9
www.frontiersin.org

Figure 9. Effect of oral PEA-um on COX-2 expression, IκB-α degradation and NF-κB p65 nuclear translocation in rat paw tissue. The levels of IκB-α decreased in paw tissue homogenates from CAR-injected rats, as compared to sham-treated rats (A,A′). Oral treatment with PEA-um (10 mg/kg) significantly recovered IκB-α levels (A,A′). NF-κB p-65 translocation significantly increased in paw tissue homogenates from CAR-injected rats, as compared to sham-treated rats (B,B′), and PEA-um significantly decreased this effect. CAR-injected rats also displayed increased COX-2 expression as compared to sham-treated rats (C,C′) which was significantly limited by oral PEA-um treatment. A representative blot of lysates obtained from five animals for each group is shown, and densitometric analysis of all animals is reported. Values are means ± SEM of five animals for each group. ###p < 0.001 vs. CAR; ***p < 0.001 vs. sham.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Keywords: absorption, hyperalgesia, inflammation, micronization, palmitoylethanolamide

Citation: Petrosino S, Cordaro M, Verde R, Moriello AS, Marcolongo G, Schievano C, Siracusa R, Piscitelli F, Peritore AF, Crupi R, Impellizzeri D, Esposito E, Cuzzocrea S and Di Marzo V (2024) Corrigendum: Oral ultramicronized palmitoylethanolamide: plasma and tissue levels and spinal antihyperalgesic effect. Front. Pharmacol. 15:1441203. doi: 10.3389/fphar.2024.1441203

Received: 30 May 2024; Accepted: 03 June 2024;
Published: 18 June 2024.

Edited and reviewed by:

Annalisa Bruno, University of Studies G. d’Annunzio Chieti and Pescara, Italy

Copyright © 2024 Petrosino, Cordaro, Verde, Moriello, Marcolongo, Schievano, Siracusa, Piscitelli, Peritore, Crupi, Impellizzeri, Esposito, Cuzzocrea and Di Marzo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Stefania Petrosino, spetrosino@icb.cnr.it

†These authors have contributed equally to this work

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.