AUTHOR=Li Xin-Lan , Sun Yan-Ping , Wang Meng , Wang Zhi-Bin , Kuang Hai-Xue 

TITLE=Alkaloids in Chelidonium majus L: a review of its phytochemistry, pharmacology and toxicology

JOURNAL=Frontiers in Pharmacology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1440979

DOI=10.3389/fphar.2024.1440979

ISSN=1663-9812

ABSTRACT=<p><italic>Chelidonium majus</italic> L. (<italic>C. majus)</italic>, commonly known as “Bai Qu Cai” in China, belongs to the genus <italic>Chelidonium</italic> of the Papaveraceae family. It has rich medicinal value, such as alleviating coughs, asthma, spasms and pain. Recent studies have demonstrated that <italic>C. majus</italic> is abundant in various alkaloids, which are the primary components of <italic>C. majus</italic> and have a range of pharmacological effects, including anti-microbial, anti-inflammatory, anti-viral, and anti-tumor effects. So far, 94 alkaloids have been isolated from <italic>C. majus</italic>, including benzophenanthridine, protoberberine, aporphine, protopine and other types of alkaloids. This paper aims to review the research progress in phytochemistry, pharmacology and toxicology of <italic>C. majus</italic> alkaloids, in order to provide a theoretical basis for the application of <italic>C. majus</italic> in the field of medicinal chemistry and to afford reference for further research and development efforts.</p>