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SYSTEMATIC REVIEW article

Front. Pharmacol.
Sec. Drugs Outcomes Research and Policies
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1440875

Management of Blood Lipids in Post-kidney Transplant Patients: A Systematic Review and Network Meta-Analysis

Provisionally accepted
Bohan Luo Bohan Luo 1,2Shan Zhong Shan Zhong 2*Xiaoxiao Wang Xiaoxiao Wang 2*Pu Guo Pu Guo 2*Yifu Hou Yifu Hou 2Wenjia Di Wenjia Di 2*
  • 1 School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China, Chengdu, China
  • 2 Organ Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, Sichuan, China, Chengdu, China

The final, formatted version of the article will be published soon.

    Introduction: this meta-analysis was to evaluate the effectiveness and safety of lipid-lowering medication therapy in post-kidney transplant (PKT) patients. Material and Methods: randomized controlled trials investigating different treatment regimens (DTRs) for regulating lipid levels in PKT patients were systematically retrieved from PubMed, Cochrane Library, and Embase, from inception to March 2024. Literature quality was assessed employing the Cochrane risk of bias assessment tool. Data analysis and graphical representation were performed employing RevMan5.3 and Stata 20.0. The surface under the cumulative ranking area (SUCRA) compared the effects of DTRs on lipid profiles, incidence of adverse events, and all-cause mortality in PKT patients. Conclusion: in reducing lipid levels in PKT patients, combination therapy with statins and ezetimibe demonstrated notable advantages and higher effectiveness. PCSK9 inhibitors exhibited greater advantages in reducing adverse events and mortality rates in PKT patients, with higher safety.

    Keywords: Post-kidney transplantation, Lipid-lowering drug therapy, Lipid profiles, adverse events, Mortality rate, Meta-analysis

    Received: 30 May 2024; Accepted: 24 Sep 2024.

    Copyright: © 2024 Luo, Zhong, Wang, Guo, Hou and Di. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Shan Zhong, Organ Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, Sichuan, China, Chengdu, China
    Xiaoxiao Wang, Organ Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, Sichuan, China, Chengdu, China
    Pu Guo, Organ Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, Sichuan, China, Chengdu, China
    Wenjia Di, Organ Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, Sichuan, China, Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.