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MINI REVIEW article

Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1439036
This article is part of the Research Topic Nano Pharmaceutical Materials Design and Therapeutic Application View all articles

Preparation Strategies of Mussel-Inspired Chitosan-based Biomaterials for Hemostasis

Provisionally accepted
Guihua Cui Guihua Cui 1*Xiaoyu Guo Xiaoyu Guo 2Li Deng Li Deng 3*
  • 1 Jilin Medical University, Jilin, China
  • 2 Jilin Vocational College of Industry and Technology, jilin, China
  • 3 The People’s Hospital of Gaozhou, Gaozhou, China

The final, formatted version of the article will be published soon.

    Chitosan (CS) has been extensively studied in wound care for its intrinsic hemostatic and antibacterial properties. However, CS has limiting hemostasis applications on account of its drawbacks such as poor adhesion in humid environments and water solubility at neutral pH. CS-based biomaterials inspired by mussel-adhesive-proteins, is a suggested platform by biomedical science. The reports show that mussel-inspired CS-based hemostatic structure has negligible toxicity and excellent adhesiveness. Biomedicine has witness significant progress in the development of this hemostatic materials. This review summarizes the methods for the modification of CS by mussel-inspired chemistry. Moreover, the general method for preparation of mussel-inspired CS-based biomaterials were briefly discussed in this review. This work is expected to give a better understanding of opportunities and challenges of mussel-inspired strategy for the functionalization of CS-based biomaterials in hemostasis and wound healing. This review is hoped to provide an important perspective on the preparation of mussel- inspired for CS-based hemostatic materials.

    Keywords: Preparation methodology, mussel-inspired strategy, CS-based biomaterials, Hemostasis, wound-healing

    Received: 27 May 2024; Accepted: 09 Jul 2024.

    Copyright: © 2024 Cui, Guo and Deng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Guihua Cui, Jilin Medical University, Jilin, China
    Li Deng, The People’s Hospital of Gaozhou, Gaozhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.