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REVIEW article

Front. Pharmacol.
Sec. Gastrointestinal and Hepatic Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1437894
This article is part of the Research Topic Gut Microbiota and Gastrointestinal Disorders - Volume II View all 4 articles

Exploring the Gut Microbiota's Crucial Role in Acute Pancreatitis and the Novel Therapeutic Potential of Derived Extracellular Vesicles Gut Microbiota in Acute Pancreatitis: Role & Therapeutic Potential of Derived Vesicles

Provisionally accepted
Yijie Li Yijie Li 1*Jie Li Jie Li 1Sen Li Sen Li 1*Shumin Zhou Shumin Zhou 2*Jiahua Yang Jiahua Yang 1*Ke Xu Ke Xu 3*Yafeng Chen Yafeng Chen 1*
  • 1 Putuo Hospital , Shanghai University of Traditional Chinese Medicine, Shanghai, China
  • 2 Wenzhou Institute of Shanghai University, Wenzhou, China
  • 3 Wenzhou Institute of Shanghai University, Wenzhou, China, Institute of Translational Medicine, Shanghai University, Shanghai, China

The final, formatted version of the article will be published soon.

    During acute pancreatitis, intestinal permeability increases due to intestinal motility dysfunction, microcirculatory disorders, and ischemia-reperfusion injury, and disturbances in the intestinal flora make bacterial translocation easier, which consequently leads to local or systemic complications such as pancreatic and peripancreatic necrotic infections, acute lung injury, systemic inflammatory response syndrome, and multiple organ dysfunction syndrome. Therefore, adjusting intestinal ecosystem balance may be a promising approach to control local and systemic complications of acute pancreatitis. In this paper, we reviewed the causes and manifestations of intestinal flora disorders during acute pancreatitis and their complications, focused on the reduction of acute pancreatitis and its complications by adjusting the intestinal microbial balance, and innovatively proposed the treatment of acute pancreatitis and its complications by gut microbiota-derived extracellular vesicles.

    Keywords: acute pancreatitis1, gut microbiota2, Gut microbiota-derived extracellular vesicles3, pathogenesis4, complications5, Complications treatment6

    Received: 24 May 2024; Accepted: 15 Jul 2024.

    Copyright: © 2024 Li, Li, Li, Zhou, Yang, Xu and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yijie Li, Putuo Hospital , Shanghai University of Traditional Chinese Medicine, Shanghai, China
    Sen Li, Putuo Hospital , Shanghai University of Traditional Chinese Medicine, Shanghai, China
    Shumin Zhou, Wenzhou Institute of Shanghai University, Wenzhou, China
    Jiahua Yang, Putuo Hospital , Shanghai University of Traditional Chinese Medicine, Shanghai, China
    Ke Xu, Wenzhou Institute of Shanghai University, Wenzhou, China, Institute of Translational Medicine, Shanghai University, Shanghai, China
    Yafeng Chen, Putuo Hospital , Shanghai University of Traditional Chinese Medicine, Shanghai, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.