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REVIEW article

Front. Pharmacol.
Sec. Integrative and Regenerative Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1437457
This article is part of the Research Topic Integrative Pharmacological Approaches for Regenerating Cartilage and Bone Tissue View all articles

Unlocking the Potential of Stimuli-responsive Biomaterials for Bone Regeneration

Provisionally accepted
Ke Yang Ke Yang 1Zhuoshu Wu Zhuoshu Wu 1Keke Zhang Keke Zhang 2Michael D. Weir Michael D. Weir 3Hockin H. Xu Hockin H. Xu 3Lei Cheng Lei Cheng 4Xiaojing Huang Xiaojing Huang 1Wen Zhou Wen Zhou 5*
  • 1 Fujian Medical University, Fuzhou, Fujian Province, China
  • 2 Wenzhou Medical University, Wenzhou, Zhejiang Province, China
  • 3 University of Maryland, Baltimore, Maryland, United States
  • 4 Sichuan University, Chengdu, Sichuan Province, China
  • 5 School of Stomatology, Fujian Medical University, Fuzhou, China

The final, formatted version of the article will be published soon.

    Bone defects caused by tumors, osteoarthritis, and osteoporosis attract great attention. Because of outstanding biocompatibility, osteogenesis promotion, and less secondary infection incidence ratio, stimuli-responsive biomaterials are increasingly used to manage this issue. These biomaterials respond to certain stimuli, changing their mechanical properties, shape, or drug release rate accordingly. Thereafter, the activated materials exert instructive or triggering effects on cells and tissues, match the properties of the original bone tissues, establish tight connection with ambient hard tissue, and provide suitable mechanical strength. In this review, basic definitions of different categories of stimuliresponsive biomaterials are presented. Moreover, possible mechanisms, advanced studies, and pros and cons of each classification are discussed and analyzed. This review aims to provide an outlook on the future developments in stimuli-responsive biomaterials.

    Keywords: Bone Regeneration, stimuli-responsive biomaterials, scaffolds, implants； composites, Hydrogels

    Received: 23 May 2024; Accepted: 18 Jul 2024.

    Copyright: © 2024 Yang, Wu, Zhang, Weir, Xu, Cheng, Huang and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Wen Zhou, School of Stomatology, Fujian Medical University, Fuzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.