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REVIEW article

Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1437019

Therapeutic implications of traditional Chinese medicine in clinically relevant diseases: Perspectives from microRNA-modulated apoptotic signaling

Provisionally accepted
Chunjie Huang Chunjie Huang 1,2*
  • 1 Nantong University, Nantong, China
  • 2 School of Medicine, Nantong University, Nantong, Jiangsu Province, China

The final, formatted version of the article will be published soon.

    For millennia, Traditional Chinese Medicines (TCMs) have been employed as a potent therapeutic modality within Chinese cultural contexts to address a spectrum of diseases, encompassing both malignant and non-malignant conditions. Herbs' therapeutic advantages often arise from their bioactive components. MicroRNAs (miRNAs) are endogenous, non-coding RNA (ncRNA) molecules that regulate genetic expression via post-transcriptional mechanisms. Recent research has revealed an evolving significance of miRNAs in both pathological and physiological phenomena, notably in processes such as apoptosis. By modulating the expression of miRNAs, TCMs have been proven to confer protective benefits, notably by facilitating apoptosis induction. Thus, exploring the molecular mechanisms implicating miRNAs within TCMs could offer potential avenues for developing novel strategies to mitigate various lethal illnesses. In this study, we aim to provide a concise overview delineating the contemporary understanding of the functions of TCMs in miRNA-mediated apoptosis across malignant and nonmalignant pathologies, including cancer, neurological disorders, and cardiovascular diseases. This review will furnish valuable insights concerning the clinical utilization of TCMs in treatment and prevention across a spectrum of clinically relevant diseases and serve as a catalyst for the innovation of novel therapeutic agents to address these pathologies.

    Keywords: Traditional Chinese Medicine, miRNAs, Apoptosis, Malignant and non-malignant pathologies, Molecular basis of TCMs in disease

    Received: 23 May 2024; Accepted: 11 Nov 2024.

    Copyright: © 2024 Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Chunjie Huang, Nantong University, Nantong, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.