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REVIEW article

Front. Pharmacol.
Sec. Renal Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1436864

Zinc: A potential star for regulating peritoneal fibrosis

Provisionally accepted
Jian Li Jian Li 1,2Xinyang Li Xinyang Li 1,2Yangwei Wang Yangwei Wang 1,2Lingfei Meng Lingfei Meng 1,2Wenpeng Cui Wenpeng Cui 1,2*
  • 1 Jilin University, Changchun, China
  • 2 Department of Nephrology, Second Hospital of Jilin University, Changchun, Jilin Province, China

The final, formatted version of the article will be published soon.

    Peritoneal dialysis (PD) is a commonly used renal replacement therapy for patients with end-stage renal disease (ESRD). During PD, the peritoneum (PM), a semipermeable membrane, is exposed to nonbiocompatible PD solutions. Peritonitis can occur, leading to structural and functional PM disorders, resulting in peritoneal fibrosis and ultrafiltration failure, which are important reasons for patients with ESRD to discontinue PD. Increasing evidence suggests that oxidative stress (OS) plays a key role in the pathogenesis of peritoneal fibrosis. Furthermore, zinc deficiency is often present to a certain extent in patients undergoing PD. As an essential trace element, zinc is also an antioxidant, potentially playing an anti-OS role and slowing down peritoneal fibrosis progression. This study summarises and analyses recent research conducted by domestic and foreign scholars on the possible mechanisms through which zinc prevents peritoneal fibrosis.

    Keywords: Peritoneal Dialysis, end-stage renal disease, Zinc, Oxidative Stress, Peritoneal Fibrosis

    Received: 22 May 2024; Accepted: 26 Aug 2024.

    Copyright: © 2024 Li, Li, Wang, Meng and Cui. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Wenpeng Cui, Jilin University, Changchun, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.