AUTHOR=Chen Leilei , Liu Yingjuan , Xie Junxia 

TITLE=The beneficial pharmacological effects of Uncaria rhynchophylla in neurodegenerative diseases: focus on alkaloids

JOURNAL=Frontiers in Pharmacology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1436481

DOI=10.3389/fphar.2024.1436481

ISSN=1663-9812

ABSTRACT=<p>With the intensification of aging population, the prevention or treatment of neurodegenerative diseases, such as Parkinson’s disease and Alzheimer’s disease, has drawn more and more attention. As a long used traditional Chinese medicine, <italic>Uncaria rhynchophylla</italic> (Miq.) Jacks., named Gouteng in Chinese, has been reported to have an effective neuroprotective role in neurodegenerative diseases. In this review, the beneficial pharmacological effects and signaling pathways of herbal formulas containing <italic>U. rhynchophylla,</italic> especially major compounds identified from <italic>U. rhynchophylla</italic>, such as corynoxine B, corynoxine, rhynchophylline, and isorhynchophylline, in neurodegenerative diseases, were summarized, which not only provide an overview of <italic>U. rhynchophylla</italic> for the prevention or treatment of neurodegenerative diseases but also give some perspective to the development of new drugs from traditional Chinese medicine.</p>