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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Ethnopharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1435222

Green Synthesis of Zinc Oxide Nanoparticles from Wodyetia bifurcata Fruit Peel Extract: Multifaceted Potential in Wound Healing, Antimicrobial, Antioxidant, and Anticancer Applications

Provisionally accepted
Adel Moalwi Adel Moalwi 1*Keerti Kamat Keerti Kamat 2*Uday M. Muddapur Uday M. Muddapur 2*Bader Aldoah Bader Aldoah 1*Hajar H. Alwadai Hajar H. Alwadai 1Abdulrahman M. Alamri Abdulrahman M. Alamri 1*Fauwaz F. Alrashid Fauwaz F. Alrashid 3Saeed Alsareii Saeed Alsareii 1Mater Mahnashi Mater Mahnashi 4*Ibrahim A. Shaikh Ibrahim A. Shaikh 4Aejaz Khan Aejaz Khan 5Sunil S. More Sunil S. More 6*
  • 1 College of Medicine, Najran University, Najran, Saudi Arabia
  • 2 KLE Technological University, Hubballi, Karnataka, India
  • 3 College of Medicine, University of Hail, Hail, Saudi Arabia
  • 4 College of Pharmacy, Najran University, Najran, Saudi Arabia
  • 5 Ibn Sina National College for Medical Studies, Jeddah, Saudi Arabia
  • 6 School of Basic and Applied Sciences, Dayananda Sagar University, Bengaluru, Karnataka, India

The final, formatted version of the article will be published soon.

    This study focuses on the synthesis, characterization, and use of zinc oxide nanoparticles (ZnONPs) derived from Wodyetia bifurcatabifurcatae (W. bifurcatae) (Foxtail palm) fruit peel extract. ZnONPs are frequently synthesized utilizing a green technique that is both costeffective and ecologically friendly. ZnONPs were characterized utilizing analytical techniques.UVUltra Violet visible (UV-Vis) visible spectra showed peaks at 364 nm, confirming the production of ZnONPs. SEM analysis indicated that the nanoparticles generated were spherical/agglomerated, with diameters ranging from 11 to 25 nm. FTIR spectroscopy was used to identify the particular functional groups responsible for the nanoparticles' reduction, stabilization, and capping. Phytochemical analysis of the extract revealed that flavonoids, saponins, steroids, triterpenoids, and resins were present. The antibacterial activity of W. Formatted: Font: (Default) +Headings CS (Times New Roman), Complex Script Font: +Headings CS (Times New Roman) Formatted: Font: (Default) +Headings CS (Times New Roman), Complex Script Font: +Headings CS (Times New Roman) . bifurcata synthesised nanoparticles was evaluated against pathogenic bacteria. The ZnONPs antioxidant activity was assessed using DPPH assay. The in vitro cytotoxicity was assessed against prostate cancer PC3 cells. The wound healing potential was assessed by employing in vitro scratch assay and in vivo excision model in Wistar rats. Because of its environmentally benign production, low toxicity, and biocompatibility, ZnONPs have potential antibacterial, antioxidant, anticancer, and wound healing activities, indicating that they could be used in cancer treatment and wound management. Further study is required to examine the fundamental mechanisms and evaluate the safety and effectiveness of the test sample in clinical situations.

    Keywords: W. bifurcata, Nanoparticles, Antibacterial activity, Wound Healing, antioxidant activity

    Received: 19 May 2024; Accepted: 19 Jul 2024.

    Copyright: © 2024 Moalwi, Kamat, Muddapur, Aldoah, Alwadai, Alamri, Alrashid, Alsareii, Mahnashi, Shaikh, Khan and More. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Adel Moalwi, College of Medicine, Najran University, Najran, Saudi Arabia
    Keerti Kamat, KLE Technological University, Hubballi, 580031, Karnataka, India
    Uday M. Muddapur, KLE Technological University, Hubballi, 580031, Karnataka, India
    Bader Aldoah, College of Medicine, Najran University, Najran, Saudi Arabia
    Abdulrahman M. Alamri, College of Medicine, Najran University, Najran, Saudi Arabia
    Mater Mahnashi, College of Pharmacy, Najran University, Najran, Saudi Arabia
    Sunil S. More, School of Basic and Applied Sciences, Dayananda Sagar University, Bengaluru, Karnataka, India

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.