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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1434136

The Structural Characterization and UV-protective Properties of an Exopolysaccharide from a Paenibacillus Isolate

Provisionally accepted
Xiadodong Xu Xiadodong Xu Zhao Ding Zhao Ding Chunlin Pu Chunlin Pu Changchang Kong Changchang Kong Shijunyin Chen Shijunyin Chen Weiling Lu Weiling Lu Jianfa Zhang Jianfa Zhang *
  • Nanjing University of Science and Technology, Nanjing, China

The final, formatted version of the article will be published soon.

    Natural polysaccharides have attracted considerable interests due to diverse biological activities. In this study, an exopolysaccharide (EPS) producing strain was isolated from a forest soil sample, and was identified as Paenibacillus sp. 1538. The average molecular weight of the EPS was 5.48×10 6 Da, composed of glucose, mannose and galactose residues at a ratio of 2:2:1. The structure of the EPS was charactered by NMR and methylation analysis, indicating the repeating units of the EPS were →3)-β-D-Glcp (1→3) [β-D-Galp (1→2)-α-D-Glcp (1→2)]-α-D-Manp (1→3)-α-D-Manp (1→. In cultural HaCaT cells, the EPS reduced cytotoxicity and excessive ROS production induced by UVB irradiation. The EPS also exhibits an inhibitory effect on oxidative stress, inflammation, and collagen degradation found in the photodamage in mice. 1 H NMR-based metabolomics analysis for skin confirmed the protective effects of the EPS in UVB-induced skin injury. In conclusion, the EPS has the potential to be developed as a natural component in sunscreen.

    Keywords: Exopolysaccharide, Paenibacillus, uvb radiation, natural sunscreen, antioxidant

    Received: 17 May 2024; Accepted: 29 Jul 2024.

    Copyright: © 2024 Xu, Ding, Pu, Kong, Chen, Lu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jianfa Zhang, Nanjing University of Science and Technology, Nanjing, China

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