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REVIEW article

Front. Pharmacol.
Sec. Predictive Toxicology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1430469

Apoptosis, Autophagy, Ferroptosis, and Pyroptosis in Cisplatin-Induced Ototoxicity and Protective Agents

Provisionally accepted
Dingyuan Dai Dingyuan Dai 1,2Chao Chen Chao Chen 1,2Chen Lu Chen Lu 1,2Yu Guo Yu Guo 1,2Qi Li Qi Li 1,2,3*Chen Sun Chen Sun 1*
  • 1 Department of ENT, Children’s Hospital of Nanjing Medical University, Nanjing, China
  • 2 Nanjing Medical University, Nanjing, Jiangsu Province, China
  • 3 Nanjing University, Nanjing, Jiangsu Province, China

The final, formatted version of the article will be published soon.

    Cisplatin (CP) is widely used to treat various solid tumors. However, its toxicity to normal tissues limits its clinical application, particularly due to its ototoxic effects, which can result in hearing loss in patients undergoing chemotherapy. While significant progress has been made in preclinical studies to elucidate the cellular and molecular mechanisms underlying cisplatin-induced ototoxicity (CIO), the precise mechanisms remain unclear. Moreover, the optimal protective agent for preventing or mitigating cisplatin-induced ototoxicity has yet to be identified. This review summarizes the current understanding of the roles of apoptosis, autophagy, ferroptosis, pyroptosis, and protective agents in cisplatin-induced ototoxicity. A deeper understanding of these cell death mechanisms in the inner ear, along with the protective agents, could facilitate the translation of these agents into clinical therapeutics, help identify new therapeutic targets, and provide novel strategies for cisplatin-based cancer treatment.

    Keywords: cisplatin1, Ototoxicity2, Apoptosis3, Autophagy4, Ferroptosis5, Pyroptosis6, Protective agents7

    Received: 10 May 2024; Accepted: 04 Sep 2024.

    Copyright: © 2024 Dai, Chen, Lu, Guo, Li and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Qi Li, Department of ENT, Children’s Hospital of Nanjing Medical University, Nanjing, China
    Chen Sun, Department of ENT, Children’s Hospital of Nanjing Medical University, Nanjing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.