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REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 15 - 2024 |
doi: 10.3389/fphar.2024.1426210
This article is part of the Research Topic Global Excellence in Ethnopharmacology: North and South America View all 5 articles
A U.S. Pharmacopeia (USP) Overview of Pan American Botanicals Used in Dietary Supplements and Herbal Medicines
Provisionally accepted
Roy Upton
1*
Ignacio Agudelo
2*
Yadira Cabrera
3*
Armando Caceres
4
Angela Calderon
5
Fernando Calzada
6*
Rosa Camacho
7*
Fernando Da Costa
8
Cecilia Dobrecky
9*
Roberto Enciso
10*
Marcela Escobar
11
Mina Fakhary
12
Edward Fletcher
13
Quanyin Gao
14*
Olga Lock
15*
Rachel Mata
16
Mirtha Parada
17*
Wilmer Perera
18
Luis M. Pombo
19
Eike Reich
20
Eric Sanchez
21*
Mario J. Simirgiotis
22
Christian Sood
23*
Virginie T. Amiguet
24*
Martha Villar
25*
Ricardo Ghelman
26*
MARIANA C. SCHVEITZER
26
Caio F. Schlechta Portella
26
Adriana Wolffenbüttel
26*
Bettina Ruppelt
26*
Fabiana Souza Frickmann
26*
Jannette Gavillan-Suarez
27
Kristin Allen
28*
Luis D. Alvarado
29*
Nandakumara Sarma
30*
Robin Marles
31*
Maria Monagas
30*
Mirtha Navarro-Hoyos
29*- 1 American Herbal Pharmacopoeia, Scotts Valley, California, United States
- 2 Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacobotánica. Universidad de Buenos Aires, Buenos Aires, Argentina
- 3 Ministerio de Salud Publica del Ecuador, Cuenca, Ecuador
- 4 Laboratorios Farmaya, Ciudad de Guatemala, Guatemala
- 5 Department of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, AL, United States
- 6 Unidad de Investigación Médica en Farmacología, UMAE Hospital de Especialidades 2° Piso CORSE. Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Cuidad de Mexico, Mexico
- 7 Direccion General de Medicamentos, Insumos y Drogas (DIGEMID), Ministerio de Salud Publica del Peru, Lima, Peru
- 8 Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidad de Sao Paulo, Ribeirao Preto, San Pablo, Brazil
- 9 Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica. Cátedra de Tecnología Farmacéutica I, Buenos Aires, Argentina
- 10 Farmacopea de los Estados Unidos Mexicanos, Cuidad de Mexico, Mexico
- 11 Facultad de Farmacia, Universidad de Valparaiso, Valparaiso, Chile
- 12 Pharmavite LLC, Valencia, CA, United States
- 13 Native Botanicals Inc., Banner Elk, NC, United States
- 14 Herbalife, Quality Control Labs, Los Angeles, CA, United States
- 15 Federacion Latinoamericana de Asociaciones Quimicas (FLAQ), Lima, Peru
- 16 Facultad de Quimica, Universidad Autonoma de Mexico (UNAM), Cuidad de Mexico, Mexico
- 17 Agencia Nacional de Medicamentos (ANAMED), Instituto de Salud Publica de Chile, Gran Santiago, Chile
- 18 CAMAG Scientific Inc., Wilmington, NC, United States
- 19 Centro de Investigacion Fundacion Universitaria Juan N. Corpas, Bogota, Colombia
- 20 CAMAG Laboratory, Muttenz, Switzerland
- 21 Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico
- 22 Instituto de Farmacia, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile
- 23 The Reena Group, Mississauga, Canada
- 24 Health Canada, Ottawa, Ontario, Canada
- 25 CICMEC, Gerencia de Medicina Complementaria, Seguro Social de Salud-EsSalud and Departamento de Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad Mayor de San Marcos, Lima, Peru
- 26 Natural Products Committee of the Brazilian Academic Consortium or Integrative Health (CABSIN), San Pablo, Brazil
- 27 TRAMIL Program, San Jose, Puerto Rico
- 28 Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, Alabama, United States
- 29 Bioactivity & Sustainable Development (BIODESS) Group, Department of Chemistry, University of Costa Rica (UCR), San Jose, Costa Rica
- 30 United States Pharmacopeial Convention (USP). Dietary Supplements and Herbal Medicines, Rockville, MD, United States
- 31 United States Pharmacopeia (USP) Botanical Dietary Supplements and Herbal Medicines Expert Committee, United States Pharmacopeia (USP), Rokcville, MD, United States
The United States Pharmacopeial Convention (USP) is a nonprofit, scientific, standard-setting organization, and world leader in establishing quality, purity, and testing standards for medicines, foods, and dietary supplements. USP quality standards are used in more than 140 countries and are legally recognized by more than 40 countries. Currently, there is renewed interest in herbal medicines globally, and health policies are being implemented worldwide for the use of complementary and traditional medicine. In response, USP has developed a robust body of monographs that can be used to guide industry and regulators in ensuring the quality and safety of botanical ingredients used in dietary supplements and herbal medicines. Throughout the Pan American regions, there is a strong tradition of using botanicals as herbal medicines and, as in other regions, a growing desire for botanical dietary supplements. This underscores the need for public quality standards to ensure quality, reduce the flow of substandard and adulterated products, and ensure public health and safety. In April 2022, USP launched the Pan America Botanical Dietary Supplements and Herbal Medicines Expert Panel, with experts representing 12 different countries. The Expert Panel's work focuses on developing quality control standards for the most important botanical ingredients used in the respective countries, ingredients that are also of global importance. This article provides an overview of the state of botanical dietary supplements and herbal medicines in different Pan American regions with a focus on the regulatory status of herbal products, the development of national quality and research initiatives, and policies related to agriculture conservation and sustainability, among other topics.Pharmacopeias are officially recognized sources of quality standards for identity, strength, purity, and limits of contaminants for ingredients and preparations used as medicines. Until approximately the 1930s, the majority of medicines formally accepted in medical practice throughout most of the world were derived from botanical ingredients. These medicines comprised a mix of crude Galenical preparations (teas, pills, tinctures, syrups, etc.) and substances isolated from plants (e.g., digitalis glycosides). Even today, the majority of the global population utilizes
Keywords: botanicals, Dietary Supplements, Standards, quality, herbal medicines
Received: 30 Apr 2024; Accepted: 29 Jul 2024.
Copyright: © 2024 Upton, Agudelo, Cabrera, Caceres, Calderon, Calzada, Camacho, Da Costa, Dobrecky, Enciso, Escobar, Fakhary, Fletcher, Gao, Lock, Mata, Parada, Perera, Pombo, Reich, Sanchez, Simirgiotis, Sood, Amiguet, Villar, Ghelman, SCHVEITZER, Schlechta Portella, Wolffenbüttel, Ruppelt, Souza Frickmann, Gavillan-Suarez, Allen, Alvarado, Sarma, Marles, Monagas and Navarro-Hoyos. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Roy Upton, American Herbal Pharmacopoeia, Scotts Valley, 95067, California, United States
Ignacio Agudelo, Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacobotánica. Universidad de Buenos Aires, Buenos Aires, Argentina
Yadira Cabrera, Ministerio de Salud Publica del Ecuador, Cuenca, Ecuador
Fernando Calzada, Unidad de Investigación Médica en Farmacología, UMAE Hospital de Especialidades 2° Piso CORSE. Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Cuidad de Mexico, Mexico
Rosa Camacho, Direccion General de Medicamentos, Insumos y Drogas (DIGEMID), Ministerio de Salud Publica del Peru, Lima, Peru
Cecilia Dobrecky, Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica. Cátedra de Tecnología Farmacéutica I, Buenos Aires, Argentina
Roberto Enciso, Farmacopea de los Estados Unidos Mexicanos, Cuidad de Mexico, Mexico
Quanyin Gao, Herbalife, Quality Control Labs, Los Angeles, CA, United States
Olga Lock, Federacion Latinoamericana de Asociaciones Quimicas (FLAQ), Lima, Peru
Mirtha Parada, Agencia Nacional de Medicamentos (ANAMED), Instituto de Salud Publica de Chile, Gran Santiago, Chile
Eric Sanchez, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico
Christian Sood, The Reena Group, Mississauga, Canada
Virginie T. Amiguet, Health Canada, Ottawa, Ontario, Canada
Martha Villar, CICMEC, Gerencia de Medicina Complementaria, Seguro Social de Salud-EsSalud and Departamento de Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad Mayor de San Marcos, Lima, Peru
Ricardo Ghelman, Natural Products Committee of the Brazilian Academic Consortium or Integrative Health (CABSIN), San Pablo, Brazil
Adriana Wolffenbüttel, Natural Products Committee of the Brazilian Academic Consortium or Integrative Health (CABSIN), San Pablo, Brazil
Bettina Ruppelt, Natural Products Committee of the Brazilian Academic Consortium or Integrative Health (CABSIN), San Pablo, Brazil
Fabiana Souza Frickmann, Natural Products Committee of the Brazilian Academic Consortium or Integrative Health (CABSIN), San Pablo, Brazil
Kristin Allen, Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849-5506, Alabama, United States
Luis D. Alvarado, Bioactivity & Sustainable Development (BIODESS) Group, Department of Chemistry, University of Costa Rica (UCR), San Jose, Costa Rica
Nandakumara Sarma, United States Pharmacopeial Convention (USP). Dietary Supplements and Herbal Medicines, Rockville, MD, United States
Robin Marles, United States Pharmacopeia (USP) Botanical Dietary Supplements and Herbal Medicines Expert Committee, United States Pharmacopeia (USP), Rokcville, MD, United States
Maria Monagas, United States Pharmacopeial Convention (USP). Dietary Supplements and Herbal Medicines, Rockville, MD, United States
Mirtha Navarro-Hoyos, Bioactivity & Sustainable Development (BIODESS) Group, Department of Chemistry, University of Costa Rica (UCR), San Jose, Costa Rica
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