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REVIEW article

Front. Pharmacol.
Sec. Ethnopharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1425955
This article is part of the Research Topic Natural Sources as Potential Therapeutic Agents against Obesity and Type-II Diabetes View all 6 articles

Therapeutic effects of natural compounds against diabetic complications via targeted modulation of ferroptosis

Provisionally accepted
Zhen Zhang Zhen Zhang Luxin Li Luxin Li Wei Fu Wei Fu *Zhengchao Fu Zhengchao Fu *Mahang Si Mahang Si *Siyu Wu Siyu Wu Yueying Shou Yueying Shou *Xinyu Pei Xinyu Pei *Xiaoyi Yan Xiaoyi Yan *Chenguang Zhang Chenguang Zhang *Tong Wang Tong Wang *Fei Liu Fei Liu *
  • Mudanjiang Medical University, Mudanjiang, China

The final, formatted version of the article will be published soon.

    Diabetes mellitus, a chronic metabolic disorder, can result in serious tissue and organ damage due to long-term metabolic dysfunction, leading to various complications. Therefore, exploring the pathogenesis of diabetic complications and developing effective prevention and treatment drugs is crucial. The role of ferroptosis in diabetic complications has emerged as a significant area of research in recent years. Ferroptosis, a recently discovered form of regulated cell death closely linked to iron metabolism imbalance and lipid peroxidation, has garnered increasing attention in studies exploring the potential role of natural products in its regulation. This review provides an overview of the mechanisms underlying ferroptosis, outlines detection methods, and synthesizes information from natural product databases. It also summarizes current research on how natural products may regulate ferroptosis in diabetic complications. Studies have shown that these products can modulate the ferroptosis process by influencing iron ion balance and combating oxidative stress. This highlights the potential of natural products in treating diabetic complications by regulating ferroptosis, offering a new strategy for managing such complications.

    Keywords: ferroptosis, Natural Products, diabetic complications, Regulatory cell death, Pathogenesis

    Received: 30 Apr 2024; Accepted: 05 Sep 2024.

    Copyright: © 2024 Zhang, Li, Fu, Fu, Si, Wu, Shou, Pei, Yan, Zhang, Wang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Wei Fu, Mudanjiang Medical University, Mudanjiang, China
    Zhengchao Fu, Mudanjiang Medical University, Mudanjiang, China
    Mahang Si, Mudanjiang Medical University, Mudanjiang, China
    Yueying Shou, Mudanjiang Medical University, Mudanjiang, China
    Xinyu Pei, Mudanjiang Medical University, Mudanjiang, China
    Xiaoyi Yan, Mudanjiang Medical University, Mudanjiang, China
    Chenguang Zhang, Mudanjiang Medical University, Mudanjiang, China
    Tong Wang, Mudanjiang Medical University, Mudanjiang, China
    Fei Liu, Mudanjiang Medical University, Mudanjiang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.