The final, formatted version of the article will be published soon.
REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 15 - 2024 |
doi: 10.3389/fphar.2024.1425955
This article is part of the Research Topic Natural Sources as Potential Therapeutic Agents against Obesity and Type-II Diabetes View all 6 articles
Therapeutic effects of natural compounds against diabetic complications via targeted modulation of ferroptosis
Provisionally accepted- Mudanjiang Medical University, Mudanjiang, China
Diabetes mellitus, a chronic metabolic disorder, can result in serious tissue and organ damage due to long-term metabolic dysfunction, leading to various complications. Therefore, exploring the pathogenesis of diabetic complications and developing effective prevention and treatment drugs is crucial. The role of ferroptosis in diabetic complications has emerged as a significant area of research in recent years. Ferroptosis, a recently discovered form of regulated cell death closely linked to iron metabolism imbalance and lipid peroxidation, has garnered increasing attention in studies exploring the potential role of natural products in its regulation. This review provides an overview of the mechanisms underlying ferroptosis, outlines detection methods, and synthesizes information from natural product databases. It also summarizes current research on how natural products may regulate ferroptosis in diabetic complications. Studies have shown that these products can modulate the ferroptosis process by influencing iron ion balance and combating oxidative stress. This highlights the potential of natural products in treating diabetic complications by regulating ferroptosis, offering a new strategy for managing such complications.
Keywords: ferroptosis, Natural Products, diabetic complications, Regulatory cell death, Pathogenesis
Received: 30 Apr 2024; Accepted: 05 Sep 2024.
Copyright: © 2024 Zhang, Li, Fu, Fu, Si, Wu, Shou, Pei, Yan, Zhang, Wang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wei Fu, Mudanjiang Medical University, Mudanjiang, China
Zhengchao Fu, Mudanjiang Medical University, Mudanjiang, China
Mahang Si, Mudanjiang Medical University, Mudanjiang, China
Yueying Shou, Mudanjiang Medical University, Mudanjiang, China
Xinyu Pei, Mudanjiang Medical University, Mudanjiang, China
Xiaoyi Yan, Mudanjiang Medical University, Mudanjiang, China
Chenguang Zhang, Mudanjiang Medical University, Mudanjiang, China
Tong Wang, Mudanjiang Medical University, Mudanjiang, China
Fei Liu, Mudanjiang Medical University, Mudanjiang, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.