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MINI REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 15 - 2024 |
doi: 10.3389/fphar.2024.1422686
This article is part of the Research Topic Mitochondria Interact With the Endoplasmic Reticulum for Myocardium Injury and Vascular Endothelial Injury Under Stress: Pathological and Targeted Therapy View all 3 articles
Advances in Pathogenesis and Treatment of Vascular Endothelial Injury-Related Diseases Mediated by Mitochondrial Abnormality
Provisionally accepted- 1 Beijing University of Chinese Medicine, Beijing, China
- 2 Beijing Anding Hospital, Capital Medical University, Beijing, Beijing Municipality, China
- 3 Department of Biosciences, University of Nottingham, Loughborough, Leicestershire, United Kingdom
- 4 National Center for Nanoscience and Technology, Chinese Academy of Sciences (CAS), Beijing, Beijing Municipality, China
- 5 Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, Beijing Municipality, China
Vascular endothelial cells, serving as a barrier between blood and the arterial wall, play a crucial role in the early stages of the development of atherosclerosis, cardiovascular diseases, and Alzheimer's disease. Mitochondria, known as the powerhouses of the cell, are not only involved in energy production but also regulate key biological processes in vascular endothelial cells, including redox signaling, cellular aging, calcium homeostasis, angiogenesis, apoptosis, and inflammatory responses. The mitochondrial quality control (MQC) system is essential for maintaining mitochondrial homeostasis. Current research indicates that mitochondrial dysfunction is a significant driver of endothelial injury and cardiovascular diseases. This article provides a comprehensive overview of the causes of endothelial injury in cardiovascular diseases, ischemic stroke in cerebrovascular diseases, and Alzheimer's disease, elucidating the roles and mechanisms of mitochondria in these conditions, and aims to develop more effective therapeutic strategies. Additionally, the article offers treatment strategies for cardiovascular and cerebrovascular diseases, including the use of clinical drugs, antioxidants, stem cell therapy, and specific polyphenols, providing new insights and methods for the clinical diagnosis and treatment of related vascular injuries to improve patient prognosis and quality of life. Future research should delve deeper into the molecular and mechanistic links between mitochondrial abnormalities and endothelial injury, and explore how to regulate mitochondrial function to prevent and treat cardiovascular diseases.
Keywords: Mitochondria abnormality, Endothelial cell injury, clinical disease, Pathogenesis, Treatment
Received: 24 Apr 2024; Accepted: 13 Aug 2024.
Copyright: © 2024 Pang, Dong, Pang, Sun, Liu, Nie and Chang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yifeng Nie, National Center for Nanoscience and Technology, Chinese Academy of Sciences (CAS), Beijing, 100190, Beijing Municipality, China
Xing Chang, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, Beijing Municipality, China
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