AUTHOR=Ren Yu , Sun Yi , Liao Yu-Ying , Wang Si , Liu Qian , Duan Chun-Yan , Sun Lan , Li Xiao-Ya , Yuan Jia-Li 

TITLE=Mechanisms of action and applications of Polygonatum sibiricum polysaccharide at the intestinal mucosa barrier: a review

JOURNAL=Frontiers in Pharmacology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1421607

DOI=10.3389/fphar.2024.1421607

ISSN=1663-9812

ABSTRACT=<p>As a medicinal and edible homologous Chinese herb, <italic>Polygonatum sibiricum</italic> has been used as a primary ingredient in various functional and medicinal products. Damage to the intestinal mucosal barrier can lead to or worsen conditions such as type 2 diabetes and Alzheimer’s disease. Traditional Chinese medicine and its bioactive components can help prevent and manage these conditions by restoring the integrity of the intestinal mucosal barrier. This review delves into the mode of action of <italic>P. sibiricum</italic> polysaccharide in disease prevention and management through the restoration of the intestinal barrier. Polysaccharide from <italic>P. sibiricum</italic> effectively treats conditions by repairing the intestinal mucosal barrier, offering insights for treating complex diseases and supporting the application of <italic>P. sibiricum</italic> in clinical settings.</p>