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REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 15 - 2024 |
doi: 10.3389/fphar.2024.1421607
This article is part of the Research Topic Restoring Barrier Function and Immunity: What Roles Can Traditional Medicines Play? View all 11 articles
Mechanisms of action and applications of Polygonatum sibiricum polysaccharide at the intestinal mucosa barrier: A review
Provisionally accepted
Yu Ren
1,2
Yi Sun
1,2*
Yu-Ying Liao
3*
Wang Si
2,4
Qian Liu
1,2*
Chun-Yan Duan
3*
Lan Sun
1,2*
Xiao-Ya Li
1,2*
Jiali Yuan
1,2*- 1 Basic Medical School, Yunnan University of Traditional Chinese Medicine, Kunming, China
- 2 Other, Kunming, China
- 3 College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, Yunnan Province, China
- 4 Yunnan University of Traditional Chinese Medicine, Kunming, China
As a medicinal and edible homologous Chinese herb, Polygonatum sibiricum has been used as a primary ingredient in various functional and medicinal products. Damage to the intestinal mucosal barrier can lead to or worsen conditions such as type 2 diabetes and Alzheimer's disease. Traditional Chinese medicine and its bioactive components can help prevent and manage these conditions by restoring the integrity of the intestinal mucosal barrier. This review delves into the mode of action of Polygonatum sibiricum polysaccharide in disease prevention and management through the restoration of the intestinal barrier. Polysaccharide from Polygonatum sibiricum effectively treats conditions by repairing the intestinal mucosal barrier, offering insights for treating complex diseases and supporting the application of Polygonatum sibiricum in clinical settings.
Keywords: Polygonatum sibiricum, Polygonatum sibiricum polysaccharide, Homology of medicine and food, Intestinal Mucosal Barrier, short-chain fatty acids
Received: 22 Apr 2024; Accepted: 01 Aug 2024.
Copyright: © 2024 Ren, Sun, Liao, Si, Liu, Duan, Sun, Li and Yuan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yi Sun, Basic Medical School, Yunnan University of Traditional Chinese Medicine, Kunming, China
Yu-Ying Liao, College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, Yunnan Province, China
Qian Liu, Basic Medical School, Yunnan University of Traditional Chinese Medicine, Kunming, China
Chun-Yan Duan, College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, Yunnan Province, China
Lan Sun, Basic Medical School, Yunnan University of Traditional Chinese Medicine, Kunming, China
Xiao-Ya Li, Basic Medical School, Yunnan University of Traditional Chinese Medicine, Kunming, China
Jiali Yuan, Basic Medical School, Yunnan University of Traditional Chinese Medicine, Kunming, China
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